Two-Quartet G-Quadruplexes Formed by DNA Sequences Containing Four Contiguous GG Runs
文献类型：期刊论文
| 作者 | Qin, Mingyan; Chen, Zhuxi; Luo, Qichao; Wen, Yi; Zhang, Naixia ; Jiang, Hualiang; Yang, Huaiyu
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| 刊名 | JOURNAL OF PHYSICAL CHEMISTRY B
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| 出版日期 | 2015-03-05 |
| 卷号 | 119期号:9页码:3706-3713 |
| ISSN号 | 1520-6106 |
| DOI | 10.1021/jp512914t |
| 文献子类 | Article |
| 英文摘要 | The DNA sequence containing four contiguous GG runs (G(2)N(x)G(2)N(y)G(2)N(z)G(2), G(2) sequence) has the potential to form a two-quartet G-quadruplex. However, the prevalence, structure, and function of G(2) sequences have not been well-studied. Here, bioinformatics analysis reveals the abundance of G(2) sequences in the human genome and their enrichment in promoter regions. The density of G(2) sequences in the genome and promoters is much higher than that of the G(3) sequence (G(3)N(x)G(3)N(y)G(3)N(z)G(3)). Experiments show that the conformations and thermal stabilities of the two-quartet G-quadruplexes of G(2) sequences are highly sensitive to the length and composition of the loops. Among the two-quartet G-quadruplexes, the parallel G-quadruplex with a loop length of 1 and the antiparallel G-quadruplex with a loop length of 3 show high thermal stabilities. Additionally, the stable parallel G-quadruplexes are stacked into intermolecular higher-order structures. This work determines the prevalence of G(2) sequences in the human genome and demonstrates that the G-quadruplex structures for certain loop lengths and compositions may be stable in vivo. Thus, more attention should be paid to the structure and function of the two-quartet G-quadruplex. |
| WOS关键词 | TELOMERIC G-QUADRUPLEX ; CIRCULAR-DICHROISM ; THROMBIN-BINDING ; LOOP-LENGTH ; STRUCTURAL DIVERSITY ; NMR-SPECTROSCOPY ; PROMOTER REGION ; SMALL-MOLECULE ; RNA SEQUENCES ; HUMAN GENOME |
| 资助项目 | National Natural Science Foundation of China[21422208] ; National Natural Science Foundation of China[81173027] ; National Natural Science Foundation of China[81230076] ; Instrument Developing Project of the Chinese Academy of Sciences[YZ201245] ; Hi-Tech Research and Development Program of China[2012AA020302] ; SA-SIBS Scholarship Program[00000000] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000350840600010 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276612]  |
| 专题 | 药物发现与设计中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yang, Huaiyu |
| 作者单位 | Chinese Acad Sci, Drug Discovery & Design Ctr, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qin, Mingyan,Chen, Zhuxi,Luo, Qichao,et al. Two-Quartet G-Quadruplexes Formed by DNA Sequences Containing Four Contiguous GG Runs[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2015,119(9):3706-3713. |
| APA | Qin, Mingyan.,Chen, Zhuxi.,Luo, Qichao.,Wen, Yi.,Zhang, Naixia.,...&Yang, Huaiyu.(2015).Two-Quartet G-Quadruplexes Formed by DNA Sequences Containing Four Contiguous GG Runs.JOURNAL OF PHYSICAL CHEMISTRY B,119(9),3706-3713. |
| MLA | Qin, Mingyan,et al."Two-Quartet G-Quadruplexes Formed by DNA Sequences Containing Four Contiguous GG Runs".JOURNAL OF PHYSICAL CHEMISTRY B 119.9(2015):3706-3713. |
入库方式： OAI收割
来源：上海药物研究所
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