Galiellalactone analogs and their possible precursors from Sarcosomataceae
文献类型：期刊论文
| 作者 | Tian, Jie-Feng1; Yu, Ru-Jian2; Li, Xiao-Xia2; Gao, Hao2; Guo, Liang-Dong3; Li, Yan4; Li, Jia5,6 ; Tang, Jin-Shan2; Yao, Xin-Sheng1,2
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2015-03 |
| 卷号 | 101页码:92-98 |
| 关键词 | Sarcosomataceae Chemical constituents Galiellalactone analogs Pregaliellalactone analogs Cytotoxicity |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2015.01.002 |
| 文献子类 | Article |
| 英文摘要 | Galiellalactone analogs (1-4) (including two new compounds), together with their possible precursors (5-9, named pregaliellalactone B-F), were obtained from the solid cultures of an endophytic fungus Sarcosomataceae NO.45-1-8-1. Their chemical structures were elucidated by analyses of HR ESI-TOF MS, 1D-, 2D-NMR, CD spectra and single crystal X-ray diffraction methods. Compounds 5-9, the possible precursors of galiellalactbne analogs, were found to exist as enantiomers for the first time. The cytotoxicity of these compounds against six tumor cell lines was examined and preliminary structure-activity relationship (SAR) was also discussed. (C) 2015 Elsevier B.V. All rights reserved. |
| WOS关键词 | ACTIVE SECONDARY METABOLITES ; ASCOMYCETE A111-95 ; INHIBITION ; CELLS ; RUFA |
| 资助项目 | Ministry of Science and Technology of China[2012ZX09301002003] ; Guangdong Natural Science Funds for Distinguished Young Scholar[S2013050014287] ; program for New Century Excellent Talents in University[NCET-10-0120] ; Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000352252700013 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276616]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 |
| 通讯作者 | Tang, Jin-Shan |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Coll Tradit Chinese Mat Med, Shenyang 110016, Peoples R China; 2.Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China; 3.Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100101, Peoples R China; 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Photochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China; 6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian, Jie-Feng,Yu, Ru-Jian,Li, Xiao-Xia,et al. Galiellalactone analogs and their possible precursors from Sarcosomataceae[J]. FITOTERAPIA,2015,101:92-98. |
| APA | Tian, Jie-Feng.,Yu, Ru-Jian.,Li, Xiao-Xia.,Gao, Hao.,Guo, Liang-Dong.,...&Yao, Xin-Sheng.(2015).Galiellalactone analogs and their possible precursors from Sarcosomataceae.FITOTERAPIA,101,92-98. |
| MLA | Tian, Jie-Feng,et al."Galiellalactone analogs and their possible precursors from Sarcosomataceae".FITOTERAPIA 101(2015):92-98. |
入库方式： OAI收割
来源：上海药物研究所
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