Reversal of doxorubicin resistance in breast cancer by mitochondria-targeted pH-responsive micelles
文献类型：期刊论文
| 作者 | Yu, Pengcheng1,2,3; Yu, Haijun2,3 ; Guo, Chengyue2,3; Cui, Zhirui2,3; Chen, Xianzhi2,3; Yin, Qi2,3; Zhang, Pengcheng2,3,4; Yang, Xiangliang1; Cui, Honggang4; Li, Yaping1,2,3
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| 刊名 | ACTA BIOMATERIALIA
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| 出版日期 | 2015-03-01 |
| 卷号 | 14页码:115-124 |
| 关键词 | Breast cancer Multidrug resistance Mitochondria Doxorubicin pH-responsive |
| ISSN号 | 1742-7061 |
| DOI | 10.1016/j.actbio.2014.12.001 |
| 文献子类 | Article |
| 英文摘要 | Chemotherapy is an important approach for clinical cancer treatment. However, the success of chemotherapy is usually hindered by the occurrence of intrinsic or acquired multidrug resistance of cancer cells. Herein, we reported an effective approach to overcome doxorubicin (DOX) resistance in MCF-7/ADR breast cancer using DOX-loaded pH-responsive micelles. The micelles were prepared from a pH-responsive diblock copolymer, poly(ethylene glycol)-block-poly(2-(diisopropylamino)ethyl methacrylate) (PEGb-PDPA), and a vitamin E derivate (D-a-tocopheryl polyethylene glycol 1000 succinate, TPGS) (denoted as PDPA/TPGS micelles). At neutral pH of 7.4, DOX was loaded into the hydrophobic core of PDPA/TPGS micelles via a film sonication method. After cellular uptake, the DOX payload was released in early endosomes by acidic pH-triggered micelle dissociation. Meanwhile, the TPGS component synergistically improved the cytotoxicity of DOX by targeting mitochondrial organelles and reducing the mitochondria] transmembrane potential. In vitro cell culture experiments using DOX-resistant MCF-7/ADR cells demonstrated that PDPAITPGS micelles reduced the IC50 of DOX by a sixfold magnitude. In vivo animal studies showed that DOX-loaded PDPA/TPGS micelles (PDPA/TPGS@DOX) inhibited tumor growth more efficiently than free DOX in a nude mouse model bearing orthotopic MCF-7/ADR tumor. All these results imply that the mitochondria-targeted pH-responsive PDPA/TPGS micelles have significant potential for efficiently combating DOX resistance in breast cancer cells. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
| WOS关键词 | P85-PEI/TPGS COMPLEX NANOPARTICLES ; MULTIDRUG-RESISTANCE ; LUNG-CANCER ; CO-DELIVERY ; CELL-DEATH ; DRUGS ; PACLITAXEL ; THERAPY ; TRANSPORTERS ; CHEMOTHERAPY |
| 资助项目 | National Basic Research Program of China[2013CB932704] ; National Basic Research Program of China[2012CB932502] ; National Natural Science Foundation of China[81373359] ; National Natural Science Foundation of China[81230029] ; SA-SIBS Scholarship Program[00000000] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000349733800012 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276631]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yu, Pengcheng |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Natl Engn Res Ctr Nanomed, Wuhan 430074, Peoples R China; 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 4.Johns Hopkins Univ, Inst NanoBio Technol, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA |
| 推荐引用方式 GB/T 7714 | Yu, Pengcheng,Yu, Haijun,Guo, Chengyue,et al. Reversal of doxorubicin resistance in breast cancer by mitochondria-targeted pH-responsive micelles[J]. ACTA BIOMATERIALIA,2015,14:115-124. |
| APA | Yu, Pengcheng.,Yu, Haijun.,Guo, Chengyue.,Cui, Zhirui.,Chen, Xianzhi.,...&Li, Yaping.(2015).Reversal of doxorubicin resistance in breast cancer by mitochondria-targeted pH-responsive micelles.ACTA BIOMATERIALIA,14,115-124. |
| MLA | Yu, Pengcheng,et al."Reversal of doxorubicin resistance in breast cancer by mitochondria-targeted pH-responsive micelles".ACTA BIOMATERIALIA 14(2015):115-124. |
入库方式： OAI收割
来源：上海药物研究所
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