Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation
文献类型：期刊论文
| 作者 | Zhang, Jie1; He, Pengxing2; Xi, Yong1; Geng, Meiyu1 ; Chen, Yi1; Ding, Jian1
|
| 刊名 | ONCOTARGET
 |
| 出版日期 | 2015-02-20 |
| 卷号 | 6期号:5页码:2917-+ |
| 关键词 | colorectal cancer G9a epigenetics DNA damage response (DDR) SN38/CPT synergistic effect |
| ISSN号 | 1949-2553 |
| DOI | 10.18632/oncotarget.2784 |
| 文献子类 | Article |
| 英文摘要 | G9a, a histone methyltransferase, is aberrantly expressed in some human tumor types. By comparing 182 paired colorectal cancer and peritumoral tissues, we found that G9a was highly expressed in colorectal cancer (CRC). Overexpression of G9a promoted CRC cells proliferation and colony formation, whereas knockdown of G9a inhibited CRC cells proliferation. Depletion of G9a increased the rate of chromosome aberration, induced DNA double strand breaks and CRC cells senescence. G9a inhibition synergistically increased gamma H2AX expression induced by topoisomerase I inhibitors and ultimately led to CRC cell death. The findings that down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation may define G9a as potential oncotarget in CRC. |
| WOS关键词 | CURATIVE RESECTION ; SENESCENT CELLS ; METHYLTRANSFERASE ; METHYLATION ; INSTABILITY ; EXPRESSION ; REPAIR |
| 资助项目 | National Basic Research Program of China[2013CB932503] ; National Natural Science Foundation of China[81273545] ; National Natural Science Foundation of China[81321092] |
| WOS研究方向 | Oncology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000352694400028 |
| 出版者 | IMPACT JOURNALS LLC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276634]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Ding, Jian |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China; 2.Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jie,He, Pengxing,Xi, Yong,et al. Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation[J]. ONCOTARGET,2015,6(5):2917-+. |
| APA | Zhang, Jie,He, Pengxing,Xi, Yong,Geng, Meiyu,Chen, Yi,&Ding, Jian.(2015).Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation.ONCOTARGET,6(5),2917-+. |
| MLA | Zhang, Jie,et al."Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation".ONCOTARGET 6.5(2015):2917-+. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。