Rh-III-Catalyzed Redox-Neutral C-H Activation of Pyrazolones: An Economical Approach for the Synthesis of N-Substituted Indoles
文献类型：期刊论文
| 作者 | Fan, Zhoulong1; Song, Shanshan2; Li, Wei3; Geng, Kaijun1; Xu, Youjun3; Miao, Ze-Hong2; Zhang, Ao1
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2015-01-16 |
| 卷号 | 17期号:2页码:310-313 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/ol503404p |
| 文献子类 | Article |
| 英文摘要 | A new strategy is reported for the economical synthesis of indoles bearing an N-(3-aminobut-2-enoyl) substituent through RhIII-catalyzed redox-neutral C-H activation of pyrazolones and alkynes. This approach utilizes cheap substrates and mild reaction conditions to access a unique class of indoles via a N-N bond oxidative cleavage without loss of the N-terminus, therefore meeting all the atom/step/redox economy principles. |
| WOS关键词 | OXIDIZING DIRECTING GROUP ; INTERNAL ALKYNES ; REGIOSELECTIVE SYNTHESIS ; BOND FUNCTIONALIZATION ; ISOQUINOLONE SYNTHESIS ; OXIDATIVE ANNULATION ; EFFICIENT SYNTHESIS ; OXIME ESTERS ; DERIVATIVES ; OXIDANT |
| 资助项目 | Chinese National Natural Science Foundation[81430080] ; Chinese National Natural Science Foundation[81125021] ; Chinese National Natural Science Foundation[81373277] ; Major State Basic Research Development Program[2015CB910603] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000348331800036 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276669]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物化学研究室 |
| 通讯作者 | Miao, Ze-Hong |
| 作者单位 | 1.Chinese Acad Sci, SIMM, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, SIMM, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan, Zhoulong,Song, Shanshan,Li, Wei,et al. Rh-III-Catalyzed Redox-Neutral C-H Activation of Pyrazolones: An Economical Approach for the Synthesis of N-Substituted Indoles[J]. ORGANIC LETTERS,2015,17(2):310-313. |
| APA | Fan, Zhoulong.,Song, Shanshan.,Li, Wei.,Geng, Kaijun.,Xu, Youjun.,...&Zhang, Ao.(2015).Rh-III-Catalyzed Redox-Neutral C-H Activation of Pyrazolones: An Economical Approach for the Synthesis of N-Substituted Indoles.ORGANIC LETTERS,17(2),310-313. |
| MLA | Fan, Zhoulong,et al."Rh-III-Catalyzed Redox-Neutral C-H Activation of Pyrazolones: An Economical Approach for the Synthesis of N-Substituted Indoles".ORGANIC LETTERS 17.2(2015):310-313. |
入库方式： OAI收割
来源：上海药物研究所
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