Phainanoids A-F, A New Class of Potent Immunosuppressive Triterpenoids with an Unprecedented Carbon Skeleton from Phyllanthus hainanensis
文献类型：期刊论文
| 作者 | Fan, Yao-Yue; Zhang, Hua; Zhou, Yu ; Liu, Hong-Bing; Tang, Wei; Zhou, Bin; Zuo, Jian-Ping; Yue, Jian-Min
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| 刊名 | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| 出版日期 | 2015-01-14 |
| 卷号 | 137期号:1页码:138-141 |
| ISSN号 | 0002-7863 |
| DOI | 10.1021/ja511813g |
| 文献子类 | Article |
| 英文摘要 | Phainanoids A-F (1-6), six highly modified triterpenoids with a new carbon skeleton by incorporating two unique motifs of a 4,5- and a 5,5-spirocyclic systems, were isolated from Phyllanthus hainanensis. Their structures with absolute configurations were determined by spectroscopic data, chemical methods, and X-ray crystallography. Compounds 1-6 exhibited exceptionally potent immunosuppressive activities in vitro against the proliferation of T and B lymphocytes. The most potent one, phainanoid F (6), showed activities against the proliferation of T cells with IC50 value of 2.04 +/- 0.01 nM (positive control CsA = 14.21 +/- 0.01 nM) and B cells with IC50 value of <1.60 +/- 0.01 nM (CsA = 352.87 +/- 0.01 nM), which is about 7 and 221 times as active as CsA, respectively. The structure-activity relationships of 1-6 are discussed. |
| WOS关键词 | KARPLUS EQUATION ; HYDROGEN-BOND ; IVORENOLIDE ; DERIVATIVES ; MACROLIDE ; PEPTIDES |
| 资助项目 | National Natural Science Foundation[U1302222] ; National Natural Science Foundation[81273398] ; National Natural Science Foundation[81321092] ; MOST of the P. R. China[2012CB721105] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000348483500035 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276672]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yue, Jian-Min |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan, Yao-Yue,Zhang, Hua,Zhou, Yu,et al. Phainanoids A-F, A New Class of Potent Immunosuppressive Triterpenoids with an Unprecedented Carbon Skeleton from Phyllanthus hainanensis[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2015,137(1):138-141. |
| APA | Fan, Yao-Yue.,Zhang, Hua.,Zhou, Yu.,Liu, Hong-Bing.,Tang, Wei.,...&Yue, Jian-Min.(2015).Phainanoids A-F, A New Class of Potent Immunosuppressive Triterpenoids with an Unprecedented Carbon Skeleton from Phyllanthus hainanensis.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,137(1),138-141. |
| MLA | Fan, Yao-Yue,et al."Phainanoids A-F, A New Class of Potent Immunosuppressive Triterpenoids with an Unprecedented Carbon Skeleton from Phyllanthus hainanensis".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 137.1(2015):138-141. |
入库方式： OAI收割
来源：上海药物研究所
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