New Securinega alkaloids with anti-HIV activity from Flueggea virosa
文献类型：期刊论文
| 作者 | Zhang, Hua1; Zhang, Chuan-Rui1; Han, Ying-Shan2; Wainberg, Mark A.2; Yue, Jian-Min1
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| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:129页码:107045-107053 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c5ra22191a |
| 文献子类 | Article |
| 英文摘要 | Chemical fractionation of the ethanolic extract of Flueggea virosa yielded a group of Securinega alkaloids including flueggenines E (1) and F (2) as novel hybrid structures, flueggenines G-I (3-5) as new dimers and fluevirosines E-H (6-9) as new trimers, along with six known biosynthetically related compounds. The diverse structures of these isolates were characterized via comprehensive spectroscopic analyses and comparison with literature data. Compounds 1 and 2 are rare Securinega alkaloid hybrids incorporating tryptamine and piperidine residues, respectively, while 3 represents the first example bearing a securinine-type monomeric unit among Securinega alkaloid dimers. An in vitro anti-HIV screening of all available alkaloids revealed weak to moderate activities for over half of these isolates with EC50 values ranging from 7.8 to 122 mu M. Among the tested compounds, the known dimer flueggenine D exhibited the best activity with an EC50 of 7.8 +/- 0.8 mu M. |
| WOS关键词 | DIMERIC INDOLIZIDINE ALKALOIDS |
| 资助项目 | National Natural Science Foundation[81322045] ; National Natural Science Foundation[21532007] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000367274300082 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276683]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 期刊编辑部 新药研究国家重点实验室 分析化学研究室 |
| 通讯作者 | Yue, Jian-Min |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Jewish Gen Hosp, Lady Davis Inst Med Res, McGill Univ Aids Ctr, Montreal, PQ H3T 1E2, Canada |
| 推荐引用方式 GB/T 7714 | Zhang, Hua,Zhang, Chuan-Rui,Han, Ying-Shan,et al. New Securinega alkaloids with anti-HIV activity from Flueggea virosa[J]. RSC ADVANCES,2015,5(129):107045-107053. |
| APA | Zhang, Hua,Zhang, Chuan-Rui,Han, Ying-Shan,Wainberg, Mark A.,&Yue, Jian-Min.(2015).New Securinega alkaloids with anti-HIV activity from Flueggea virosa.RSC ADVANCES,5(129),107045-107053. |
| MLA | Zhang, Hua,et al."New Securinega alkaloids with anti-HIV activity from Flueggea virosa".RSC ADVANCES 5.129(2015):107045-107053. |
入库方式： OAI收割
来源：上海药物研究所
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