Receptor-targeting fluorescence imaging and theranostics using a graphene oxide based supramolecular glycocomposite
文献类型：期刊论文
| 作者 | Ji, Ding-Kun1,2; Zhang, Yue1,2,3; Zang, Yi3 ; Liu, Wang4; Zhang, Xiongwen4; Li, Jia3; Chen, Guo-Rong1,2; James, Tony D.5; He, Xiao-Peng1,2
|
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2015 |
| 卷号 | 3期号:47页码:9182-9185 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/c5tb02057c |
| 文献子类 | Article |
| 英文摘要 | Intercellular glycoligand-receptor interactions are implicated in a number of disease-related processes. Effective tools that target these receptors may facilitate disease theranostics. However, owing to their low binding affinity, multivalent presentation of glycoligands is needed to increase the avidity with transmembrane receptors. While previous strategies focus on the covalent coupling of glycoligands to a synthetic backbone, we show here that the use of graphene oxide (GO) greatly enhances the cellular and tissue imaging ability of a small-molecule fluorescence glycoprobe. We determine that GO with an optimum size may serve as a clustering platform to reinforce the interaction of the glycoprobe with its selective receptor on a cancer cell. This phenomenon has been consistently observed with the xenograft tissue of a tumor-bearing mouse. Using this principle we have further constructed a supramolecular glycocomposite by co-assembling the glycoprobe and an anticancer drug onto a single GO surface. In addition to imaging ability, this material displays improved toxicity for liver cancer cells that over express the glycoprotein receptor, when compared to the control cells. |
| WOS关键词 | RECOGNITIONS ; COMPOSITE ; PLATFORM ; GLYCOBIOLOGY ; DISACCHARIDE ; BLEOMYCIN ; LIGANDS ; DISEASE ; LECTIN ; CELLS |
| 资助项目 | 973 project[2013CB733700] ; Fundamental Research Funds for Central Universities[222201414010] ; Key Project of Shanghai Science and Technology Commission[13NM1400900] ; National Science Foundation of China[21572058] ; National Science Foundation of China[21576088] ; National Science Foundation of China[91213303] |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000365532000012 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276686]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zang, Yi |
| 作者单位 | 1.E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; 2.E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China; 4.E China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Inst Drug Discovery & Dev, Shanghai 200062, Peoples R China; 5.Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England |
| 推荐引用方式 GB/T 7714 | Ji, Ding-Kun,Zhang, Yue,Zang, Yi,et al. Receptor-targeting fluorescence imaging and theranostics using a graphene oxide based supramolecular glycocomposite[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(47):9182-9185. |
| APA | Ji, Ding-Kun.,Zhang, Yue.,Zang, Yi.,Liu, Wang.,Zhang, Xiongwen.,...&He, Xiao-Peng.(2015).Receptor-targeting fluorescence imaging and theranostics using a graphene oxide based supramolecular glycocomposite.JOURNAL OF MATERIALS CHEMISTRY B,3(47),9182-9185. |
| MLA | Ji, Ding-Kun,et al."Receptor-targeting fluorescence imaging and theranostics using a graphene oxide based supramolecular glycocomposite".JOURNAL OF MATERIALS CHEMISTRY B 3.47(2015):9182-9185. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。