Identification of hepatoprotective xanthones from the pericarps of Garcinia mangostana, guided with tert-butyl hydroperoxide induced oxidative injury in HL-7702 cells
文献类型：期刊论文
| 作者 | Wang, Anqi1; Liu, Qianyu1; Ye, Yang2 ; Wang, Yitao1; Lin, Ligen1
|
| 刊名 | FOOD & FUNCTION
 |
| 出版日期 | 2015 |
| 卷号 | 6期号:9页码:3013-3021 |
| ISSN号 | 2042-6496 |
| DOI | 10.1039/c5fo00573f |
| 文献子类 | Article |
| 英文摘要 | Bioactivity-guided fractionation of an ethanol-soluble extract from the pericarps of Garcinia mangostana, using tert-butyl hydroperoxide (t-BHP) induced oxidative damage in human normal hepatocytes (HL-7702), led to the identification of 10 known xanthones. Among them, gamma-mangostin (gamma-Man) exhibited the most potent activity to attenuate t-BHP induced hepatocyte injury gamma-Man significantly ameliorated t-BHP induced reactive oxygen species accumulation, mitochondrial membrane depolarization and cell nuclei morphology change in HL-7702 cells. t-BHP decreased the intracellular levels of key enzymes including glutamate oxaloacetate transaminase and glutamate pyruvate transaminase, which was totally reversed by gamma-Man. Moreover, gamma-Man significantly decreased the level of lipid peroxidation and increased the levels of superoxide dismutase and reduced glutathione, resulting in the alleviation of oxidative stress. The above results suggest.-Man is a potential hepatoprotective agent against t-BHP induced oxidative injury, which may benefit the further application of G. mangostana as a health food. |
| WOS关键词 | ANTIOXIDANT CAPACITY ; STRESS ; APOPTOSIS ; DISEASE ; ROS ; MECHANISMS ; INDUCTION ; EXTRACT |
| 资助项目 | Science and Technology Development Fund, Macao S.A.R[FDCT 120/2013/A3] ; Research Fund of University of Macau[MYRG2014-00020-ICMS-QRCM] ; Research Fund of University of Macau[MYRG2015-00153-ICMS-QRCM] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Food Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:000360636300013 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276706]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Wang, Anqi |
| 作者单位 | 1.Univ Macau, State Key Lab Qual Res Chinese Med, Inst Chinese Med Sci, Taipa, Macau, Peoples R China; 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Anqi,Liu, Qianyu,Ye, Yang,et al. Identification of hepatoprotective xanthones from the pericarps of Garcinia mangostana, guided with tert-butyl hydroperoxide induced oxidative injury in HL-7702 cells[J]. FOOD & FUNCTION,2015,6(9):3013-3021. |
| APA | Wang, Anqi,Liu, Qianyu,Ye, Yang,Wang, Yitao,&Lin, Ligen.(2015).Identification of hepatoprotective xanthones from the pericarps of Garcinia mangostana, guided with tert-butyl hydroperoxide induced oxidative injury in HL-7702 cells.FOOD & FUNCTION,6(9),3013-3021. |
| MLA | Wang, Anqi,et al."Identification of hepatoprotective xanthones from the pericarps of Garcinia mangostana, guided with tert-butyl hydroperoxide induced oxidative injury in HL-7702 cells".FOOD & FUNCTION 6.9(2015):3013-3021. |
入库方式： OAI收割
来源：上海药物研究所
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