中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 天然药物化学研究室
Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94

文献类型：期刊论文

作者Zhou, Zhenfang1; Wang, Xin1; Zhang, Hui2; Sun, Jingya1; Zheng, Linghui2; Liu, Hongchun1; Wang, Jidong2; Shen, Aijun1; Geng, Meiyu1; Guo, Yuewei1
刊名ACTA PHARMACEUTICA SINICA B
出版日期2015-01
卷号5期号:1页码:62-66
关键词Chromopeptide A Bacterium Depsipeptide Absolute configuration Marine derived Sediments Cytotoxicity Chromobacterium sp.
ISSN号2211-3835
DOI10.1016/j.apsb.2014.11.001
文献子类Article
英文摘要A bicyclic depsipeptide, chromopeptide A (1), was isolated from a deep-sea-derived bacterium Chromobacterium sp. HS-13-94. Its structure was determined by extensive spectroscopic analysis and by comparison with a related known compound. The absolute configuration of chromopeptide A was established by X-ray diffraction analysis employing graphite monochromated Mo K-alpha radiation (lambda=0.71073 angstrom) with small Flack parameter 0.03. Chromopeptide A suppressed the proliferation of HL-60. K-562, and Ramos cells with average IC50 values of 7,7, 7.0, and 16,5 nmol/L, respectively. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. All rights reserved.
WOS关键词FR901228 ; FK228
资助项目National Marine '863' Project[20112AA092105] ; National Marine '863' Project[20113AA092902] ; National Natural Science Foundation of China[81273430]
WOS研究方向Pharmacology & Pharmacy
语种英语
CSCD记录号CSCD:5392968
WOS记录号WOS:000360008000008
出版者INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
源URL[http://119.78.100.183/handle/2S10ELR8/276715]  
专题天然药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
药物化学研究室
药理学第一研究室
分子影像中心（筹）
通讯作者Wang, Jidong
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
2.Zhejiang Hisun Pharmaceut Co Ltd, Thizhou 318000, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Zhenfang,Wang, Xin,Zhang, Hui,et al. Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94[J]. ACTA PHARMACEUTICA SINICA B,2015,5(1):62-66.
APA Zhou, Zhenfang.,Wang, Xin.,Zhang, Hui.,Sun, Jingya.,Zheng, Linghui.,...&Guo, Yuewei.(2015).Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94.ACTA PHARMACEUTICA SINICA B,5(1),62-66.
MLA Zhou, Zhenfang,et al."Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94".ACTA PHARMACEUTICA SINICA B 5.1(2015):62-66.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。