Spiroplakortone, an unprecedented spiroketal lactone from the Chinese sponge Plakortis simplex
文献类型：期刊论文
| 作者 | Chianese, Giuseppina1; Gu, Bin-Bin2; Yang, Fan2; Jiao, Wei-Hua2; Guo, Yue-Wei3 ; Lin, Hou-Wen2; Taglialatela-Scafati, Orazio1
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| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:78页码:63372-63376 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c5ra09840h |
| 文献子类 | Article |
| 英文摘要 | A new polyketide-based metabolite, spiroplakortone (1), characterized as an unprecedented gamma-spiroketalg-lactone, was obtained from the Chinese sponge Plakortis simplex. Structural characterization of spiroplakortone (1) was based on extensive spectroscopic analysis and its configuration was partly established by GIAO C-13-NMR, supported by DP4 probability analysis, and ECD calculations. A plausible pathway for the biosynthesis of spiroplakortone (1), envisaging the formation of a carbon-carbon linkage between polyketide and aminoacid (leucine)-derived moieties, has been proposed. |
| WOS关键词 | NATURAL-PRODUCTS ; POLYKETIDES ; METABOLITES ; HALICHONDRIOIDES ; STEREOCHEMISTRY ; 1,2-DIOXANES |
| 资助项目 | EU[311848] ; EU[246987] ; China National Funds for Distinguished Young Scientists[81225023] ; NSFC[41106127] ; NSFC[81202441] ; NSFC[41476121] ; NSFC[81302691] ; NSFC[81172978] ; MOST grants (863 Projects)[2013AA092902] ; STCSM[14QA1402800] ; STCSM[14YZ037] ; STCSM[14431901300] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000358734800028 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276718]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Taglialatela-Scafati, Orazio |
| 作者单位 | 1.Univ Naples Federico II, Dipartimento, Farm, I-80131 Naples, Italy; 2.Renji Hosp, Sch Med, State Key Lab Oncogenes & Related Genes, Key Lab Marine Drugs,Dept Pharm, Shanghai 200127, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chianese, Giuseppina,Gu, Bin-Bin,Yang, Fan,et al. Spiroplakortone, an unprecedented spiroketal lactone from the Chinese sponge Plakortis simplex[J]. RSC ADVANCES,2015,5(78):63372-63376. |
| APA | Chianese, Giuseppina.,Gu, Bin-Bin.,Yang, Fan.,Jiao, Wei-Hua.,Guo, Yue-Wei.,...&Taglialatela-Scafati, Orazio.(2015).Spiroplakortone, an unprecedented spiroketal lactone from the Chinese sponge Plakortis simplex.RSC ADVANCES,5(78),63372-63376. |
| MLA | Chianese, Giuseppina,et al."Spiroplakortone, an unprecedented spiroketal lactone from the Chinese sponge Plakortis simplex".RSC ADVANCES 5.78(2015):63372-63376. |
入库方式： OAI收割
来源：上海药物研究所
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