Design, synthesis, and anticancer activities of new compounds bearing the quinone-pyran-lactone tricyclic pharmacophore
文献类型：期刊论文
| 作者 | Jiang, Xue1; Wang, Meining2; Song, Shanshan3; Xu, Youjun1; Miao, Zehong3; Zhang, Ao2
|
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:35页码:27502-27508 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c5ra00154d |
| 文献子类 | Article |
| 英文摘要 | A simple and more effective four-step synthesis of the tricyclic quinone-pyran-lactone skeleton was developed. Subsequent structural modification led to several series of derivatives. Regio- and diastereo-characteristics of these compounds were elucidated, and their antitumor activities against several cancer cells were investigated. |
| WOS关键词 | BIOLOGICAL-ACTIVITY ; PYRANONAPHTHOQUINONE ANTIBIOTICS ; KINASE INHIBITORS ; CRISAMICIN ; KALAFUNGIN ; GRANATICIN |
| 资助项目 | Chinese National Natural Science Foundation[81373277] ; Chinese National Natural Science Foundation[81430080] ; Chinese National Natural Science Foundation[81125021] ; Major State Basic Research Development Program[2015CB910603] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000351556100040 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276749]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物化学研究室 |
| 通讯作者 | Xu, Youjun |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res Synthet Organ & Med Chem, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Xue,Wang, Meining,Song, Shanshan,et al. Design, synthesis, and anticancer activities of new compounds bearing the quinone-pyran-lactone tricyclic pharmacophore[J]. RSC ADVANCES,2015,5(35):27502-27508. |
| APA | Jiang, Xue,Wang, Meining,Song, Shanshan,Xu, Youjun,Miao, Zehong,&Zhang, Ao.(2015).Design, synthesis, and anticancer activities of new compounds bearing the quinone-pyran-lactone tricyclic pharmacophore.RSC ADVANCES,5(35),27502-27508. |
| MLA | Jiang, Xue,et al."Design, synthesis, and anticancer activities of new compounds bearing the quinone-pyran-lactone tricyclic pharmacophore".RSC ADVANCES 5.35(2015):27502-27508. |
入库方式： OAI收割
来源：上海药物研究所
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