Interaction Between DNA/histone Methyltransferases and their Inhibitors
文献类型：期刊论文
| 作者 | Hu, J.; Chen, S.; Kong, X.; Zhu, K.; Cheng, S.; Zheng, M.; Jiang, H.; Luo, C.
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| 刊名 | CURRENT MEDICINAL CHEMISTRY
 |
| 出版日期 | 2015 |
| 卷号 | 22期号:3页码:360-372 |
| ISSN号 | 0929-8673 |
| 关键词 | DNA methyltransferase drug discovery epigenetic therapy histone methyltransferase inhibitor |
| 文献子类 | Article |
| 英文摘要 | Epigenetic research has recently become one of the hotspots in the field of bioscience and drug design. DNA methylation and histone methylation serve a critical function in influencing gene expression and genome function. The inhibition of DNA and histone methyltransferases (DNMTs and HMTs) is a promising approach for the therapeutic treatment of numerous diseases, including cancer. This work reviews the recent achievements in methyltransferase crystallographic structure resolution and bioactive inhibitor screening. We discuss the features of DNA and HMT structures, as well as the mechanism and structure- function relationship of transferase inhibitors, to elucidate how methyltransferase and inhibitor interactions occur both internally and externally. This study briefly reviews the biological function, as well as the inhibitor discovery and development, of DNA/histone methyltransferases. |
| WOS关键词 | SMALL-MOLECULE INHIBITORS ; TUMOR-SUPPRESSOR GENES ; PROTEIN ARGININE METHYLTRANSFERASES ; DNA METHYLTRANSFERASE ; HISTONE METHYLTRANSFERASE ; LYSINE METHYLTRANSFERASE ; STRUCTURAL BASIS ; SELECTIVE-INHIBITION ; PYRAZOLE INHIBITORS ; CELLULAR-ACTIVITY |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| WOS记录号 | WOS:000349386900006 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276763]  |
| 专题 | 药物发现与设计中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物化学研究室 |
| 通讯作者 | Luo, C. |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, J.,Chen, S.,Kong, X.,et al. Interaction Between DNA/histone Methyltransferases and their Inhibitors[J]. CURRENT MEDICINAL CHEMISTRY,2015,22(3):360-372. |
| APA | Hu, J..,Chen, S..,Kong, X..,Zhu, K..,Cheng, S..,...&Luo, C..(2015).Interaction Between DNA/histone Methyltransferases and their Inhibitors.CURRENT MEDICINAL CHEMISTRY,22(3),360-372. |
| MLA | Hu, J.,et al."Interaction Between DNA/histone Methyltransferases and their Inhibitors".CURRENT MEDICINAL CHEMISTRY 22.3(2015):360-372. |
入库方式： OAI收割
来源：上海药物研究所
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