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Diels-Alder adducts with PTP1B inhibition from Morus notabilis

文献类型：期刊论文

作者Wang, Meng1; Gao, Li-Xin2; Wang, Jue1; Li, Jing-Ya2; Yu, Mei-Hua1; Li, Jia2; Hou, Ai-Jun1
刊名PHYTOCHEMISTRY
出版日期2015-01
卷号109页码:140-146
ISSN号0031-9422
关键词Morus notabilis Moraceae Diels-Alder adducts Morbilisins A-H Protein tyrosine phosphatase 1B
DOI10.1016/j.phytochem.2014.10.015
文献子类Article
英文摘要Eight Diels-Alder adducts, morbilisins A-H (1-8), a known analogue, chalcomoracin (9), together with eleven known flavonoids and 2-arylbenzofurans, were isolated from the leaves of Moms notabilis. Their structures were elucidated by extensive spectroscopic analysis, including 1D, 2D NMR, MS, and ECD data. Compounds 1, 5, and 7-9 showed inhibition against PTP1B phosphatase activity in vitro. (C) 2014 Elsevier Ltd. All rights reserved.
WOS关键词TYROSINE-PHOSPHATASE 1B ; ADIPOGENESIS-PROMOTING CONSTITUENTS ; ISOPRENYLATED FLAVONOIDS ; ROOT BARK ; 2-ARYLBENZOFURAN DERIVATIVES ; DISEASED MULBERRY ; MORACIN-C ; PROTEIN ; PHYTOALEXINS ; WITTIORUM
资助项目National Natural Science Foundation of China[81222045] ; National Natural Science Foundation of China[21072035] ; National Natural Science Foundation of China[81125023] ; Shanghai Municipal Education Commission[12SG02] ; Shanghai Education Development Foundation[12SG02]
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
出版者PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号WOS:000347769400016
源URL[http://119.78.100.183/handle/2S10ELR8/276771]  
专题国家新药筛选中心
中科院受体结构与功能重点实验室
新药研究国家重点实验室
药物安全性评价中心
通讯作者Hou, Ai-Jun
作者单位1.Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 201203, Peoples R China;
2.Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai Inst Mat Medica, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Meng,Gao, Li-Xin,Wang, Jue,et al. Diels-Alder adducts with PTP1B inhibition from Morus notabilis[J]. PHYTOCHEMISTRY,2015,109:140-146.
APA Wang, Meng.,Gao, Li-Xin.,Wang, Jue.,Li, Jing-Ya.,Yu, Mei-Hua.,...&Hou, Ai-Jun.(2015).Diels-Alder adducts with PTP1B inhibition from Morus notabilis.PHYTOCHEMISTRY,109,140-146.
MLA Wang, Meng,et al."Diels-Alder adducts with PTP1B inhibition from Morus notabilis".PHYTOCHEMISTRY 109(2015):140-146.

入库方式： OAI收割

来源：上海药物研究所

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