9,11-Secosteroids and polyhydroxylated steroids from two South China Sea soft corals Sarcophyton trocheliophorum and Sinularia flexibilis
文献类型：期刊论文
| 作者 | Chen, Wen-Ting; Liu, Hai-Li; Yao, Li-Gong; Guo, Yue-Wei
|
| 刊名 | STEROIDS
 |
| 出版日期 | 2014-12-15 |
| 卷号 | 92页码:56-61 |
| 关键词 | Soft coral Sarcophyton trocheliophorum Sinularia flexibilis 9,11-Secosteroid Polyhydroxylated steroid |
| ISSN号 | 0039-128X |
| DOI | 10.1016/j.steroids.2014.08.027 |
| 文献子类 | Article |
| 英文摘要 | A new 9,11-secosteroid, 25(26)-dehydrosarcomilasterol (1), two new polyhydroxylated steroids, 7 alpha-hydroxy-crassarosterol A (2) and 11-acetoxy-7 alpha-hydroxy-crassarosterol A (3), together with three known related ones (4-6), were isolated from the South China Sea soft corals Sarcophyton trocheliophorum and Sinularia flexibilis, respectively. The structures of the new steroids were elucidated on the basis of extensive spectroscopic analyses, comparison with the literature data and chemical correlation. Compound 2 exhibited a moderate protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with an IC50 value of 33.05 mu M. Compounds 1-3 showed weak in vitro cytotoxicities against the tumor cell lines 1(562 and HL-60. (C) 2014 Elsevier Inc. All rights reserved. |
| WOS关键词 | POLYOXYGENATED STEROIDS ; SUBERGORGIA-SUBEROSA ; MUSA-SAPIENTUM ; INDIAN-OCEAN ; DITERPENOIDS ; LEPTOCLADOS ; METABOLITES ; INHIBITOR ; CHEMISTRY |
| 资助项目 | National Marine '863' Projects[2011AA09070102] ; National Marine '863' Projects[2013AA092902] ; Natural Science Foundation of China[81273430] ; SKLDR/SIMM Project[SIMM1203ZZ-03] ; SKLNM/CPU Project[SKLNMKF201412] ; EU[246987] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000347134300009 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276800]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Guo, Yue-Wei |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Wen-Ting,Liu, Hai-Li,Yao, Li-Gong,et al. 9,11-Secosteroids and polyhydroxylated steroids from two South China Sea soft corals Sarcophyton trocheliophorum and Sinularia flexibilis[J]. STEROIDS,2014,92:56-61. |
| APA | Chen, Wen-Ting,Liu, Hai-Li,Yao, Li-Gong,&Guo, Yue-Wei.(2014).9,11-Secosteroids and polyhydroxylated steroids from two South China Sea soft corals Sarcophyton trocheliophorum and Sinularia flexibilis.STEROIDS,92,56-61. |
| MLA | Chen, Wen-Ting,et al."9,11-Secosteroids and polyhydroxylated steroids from two South China Sea soft corals Sarcophyton trocheliophorum and Sinularia flexibilis".STEROIDS 92(2014):56-61. |
入库方式： OAI收割
来源：上海药物研究所
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