Racemosin C, a novel minor bisindole alkaloid with protein tyrosine phosphatase-1B inhibitory activity from the green alga Caulerpa racemosa
文献类型：期刊论文
| 作者 | Yang, Hui1; Liu, Ding-Quan1; Liang, Tong-Jun2,3; Li, Jia4 ; Liu, Ai-Hong5; Yang, Peng1; Lin, Kun1; Yu, Xiao-Qing1; Guo, Yue-Wei4; Mao, Shui-Chun1
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| 刊名 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
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| 出版日期 | 2014-12-02 |
| 卷号 | 16期号:12页码:1158-1165 |
| 关键词 | Caulerpa racemosa PTP1B inhibitory activity bisindole alkaloid racemosin C green alga |
| ISSN号 | 1028-6020 |
| DOI | 10.1080/10286020.2014.965162 |
| 文献子类 | Article |
| 英文摘要 | A novel minor bisindole alkaloid, racemosin C (1), characterized by a naturally unprecedented 8-hydroxy-2,4,6-cyclooctatrienone ring fused with two indole systems, was isolated from the green alga Caulerpa racemosa, together with one known related metabolite, caulersin (2). The structure of 1 was elucidated on the basis of extensive spectroscopic analysis, and by comparison with the data of related known compounds. A plausible biosynthetic pathway of 1 was proposed. Compounds 1 and 2 exhibited significant PTP1B inhibitory activity with IC50 values of 5.86 +/- 0.57 and 7.14 +/- 1.00 mu M, respectively, compared with the positive control oleanolic acid (IC50=3.03 +/- 0.20 mu M). On the basis of the data obtained, the Caulerpa bisindole alkaloids may be considered as a new class of PTP1B inhibitors. |
| WOS关键词 | TAXIFOLIA ; ANALOGS ; SESQUITERPENES |
| 资助项目 | National Natural Science Foundation of China[81001397] ; National Natural Science Foundation of China[21162016] ; National Natural Science Foundation of China[21362024] ; Young Scientists Training Program of Jiangxi Province[20133BCB23004] ; Natural Science Foundation of Jiangxi Province[20114BAB205034] |
| WOS研究方向 | Plant Sciences ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000347699700008 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276808]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 天然药物化学研究室 药物安全性评价中心 |
| 通讯作者 | Mao, Shui-Chun |
| 作者单位 | 1.Nanchang Univ, Sch Pharm, Nanchang 330006, Peoples R China; 2.Lushan Bot Garden, Lushan, Jiangxi, Peoples R China; 3.Chinese Acad Sci, Lushan 332900, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 5.Nanchang Univ, Ctr Anal & Testing, Nanchang 330047, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Hui,Liu, Ding-Quan,Liang, Tong-Jun,et al. Racemosin C, a novel minor bisindole alkaloid with protein tyrosine phosphatase-1B inhibitory activity from the green alga Caulerpa racemosa[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2014,16(12):1158-1165. |
| APA | Yang, Hui.,Liu, Ding-Quan.,Liang, Tong-Jun.,Li, Jia.,Liu, Ai-Hong.,...&Wang, Bin.(2014).Racemosin C, a novel minor bisindole alkaloid with protein tyrosine phosphatase-1B inhibitory activity from the green alga Caulerpa racemosa.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,16(12),1158-1165. |
| MLA | Yang, Hui,et al."Racemosin C, a novel minor bisindole alkaloid with protein tyrosine phosphatase-1B inhibitory activity from the green alga Caulerpa racemosa".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 16.12(2014):1158-1165. |
入库方式： OAI收割
来源：上海药物研究所
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