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Two New N-Oxide Alkaloids from Stemona cochinchinensis

文献类型：期刊论文

作者Lin, Ligen1,2; Bao, Han1; Wang, Anqi1; Tang, Chunping2; Pham-Huu Dien3; Ye, Yang2
刊名MOLECULES
出版日期2014-12
卷号19期号:12页码:20257-20265
关键词Stemona cochinchinensis Stemonaceae N-oxide alkaloids H-1- and C-13-NMR anti-tussive activity
ISSN号1420-3049
DOI10.3390/molecules191220257
文献子类Article
英文摘要Two new N-oxide alkaloids with pyrrolo[1,2-alpha]azepine skeleton, namely isoneostemocochinine-N-oxide (1) and neostemocochinine-N-oxide (2), as well as three known alkaloids with pyrido[1,2-alpha]azepine skeletons, were isolated and identified from the roots of Stemona cochinchinensis (Stemonaceae). The structures of these compounds were elucidated by 1D- and 2D-NMR spectra and other spectroscopic studies. Additionally, the H-1- and C-13-NMR characteristic of N-oxide Stemona alkaloids was summarized. Stemokerrin showed potent anti-tussive activity on citric acid-induced guinea pig model.
WOS关键词ROOTS ; STEMOCURTISINE ; CURTISII
资助项目Macao Science and Technology Development Fund[042/2013/A2] ; Research Fund of University of Macau[MRG015/LLG/2014/ICMS] ; Research Fund of University of Macau[MYRG2014-00020-ICMS-QRCM] ; Vietnam NAFOSTED[104.01-2012.14]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000346793200055
出版者MDPI AG
源URL[http://119.78.100.183/handle/2S10ELR8/276811]  
专题天然药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Lin, Ligen
作者单位1.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
3.Hanoi Natl Univ Educ, Fac Chem, Dept Organ Chem, Hanoi 100000, Vietnam
推荐引用方式
GB/T 7714		 Lin, Ligen,Bao, Han,Wang, Anqi,et al. Two New N-Oxide Alkaloids from Stemona cochinchinensis[J]. MOLECULES,2014,19(12):20257-20265.
APA Lin, Ligen,Bao, Han,Wang, Anqi,Tang, Chunping,Pham-Huu Dien,&Ye, Yang.(2014).Two New N-Oxide Alkaloids from Stemona cochinchinensis.MOLECULES,19(12),20257-20265.
MLA Lin, Ligen,et al."Two New N-Oxide Alkaloids from Stemona cochinchinensis".MOLECULES 19.12(2014):20257-20265.

入库方式： OAI收割

来源：上海药物研究所

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