Xanthine Oxidase Inhibitors from Garcinia esculenta Twigs
文献类型：期刊论文
| 作者 | Zhu, Lun-Lun1,2; Fu, Wen-Wei1,2; Watanabe, Shimpei3; Shao, Yi-Nuo1,2; Tan, Hong-Sheng1,2; Zhang, Hong1,2; Tan, Chang-Heng4 ; Xiu, Yan-Feng1,2; Norimoto, Hisayoshi3; Xu, Hong-Xi1,2
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| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2014-12 |
| 卷号 | 80期号:18页码:1721-1726 |
| 关键词 | Garcinia esculenta Clusiaceae xanthine oxidase inhibitor 1,3,6,7-tetrahydroxy-xanthone griffipavixanthone |
| ISSN号 | 0032-0943 |
| DOI | 10.1055/s-0034-1383193 |
| 文献子类 | Article |
| 英文摘要 | The EtOAc-soluble portion of the 80% (v/v) EtOH extract from the twigs of Garcinia esculenta exhibited strong xanthine oxidase inhibition in vitro. Bioassay-guided purification led to the isolation of 1,3,6,7-tetrahydroxyxanthone (3) and griffipavixanthone (8) as the main xanthine oxidase inhibitors, along with six additional compounds (1, 2, 4-7), including two new compounds (1 and 2). This enzyme inhibition was dose dependent with an IC50 value of approximately 1.2 mu M for 3 and 6.3 mu M for 8. The inhibitory activity of 3 was stronger than the control allopurinol (IC50 value: 5.3 mu M). To our knowledge, compound 8 is the first bixanthone that demonstrated potent XO inhibitory activity in vitro. The structures of the new compounds were established by spectroscopic analysis, and the optical properties and absolute stereochemistry of racemic (+/-) esculentin A (2) were further determined by the calculation of the DP4 probability and analysis of its MTPA ester derivatives. |
| WOS关键词 | BIOASSAY-GUIDED ISOLATION ; XANTHONES ; ACYLPHLOROGLUCINOLS ; SPECTROSCOPY ; DERIVATIVES ; LANCILIMBA ; PREDICTION ; CHEMISTRY ; DISCOVERY ; CELLS |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000346411300009 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276812]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Xu, Hong-Xi |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China; 2.Shanghai Coll TCM New Drug Discovery, Engn Res Ctr, Shanghai, Peoples R China; 3.Kracie Pharma Ltd, Kampo Res Labs, Takaoka, Toyama, Japan; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Drug Res, Inst Mat Med, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Lun-Lun,Fu, Wen-Wei,Watanabe, Shimpei,et al. Xanthine Oxidase Inhibitors from Garcinia esculenta Twigs[J]. PLANTA MEDICA,2014,80(18):1721-1726. |
| APA | Zhu, Lun-Lun.,Fu, Wen-Wei.,Watanabe, Shimpei.,Shao, Yi-Nuo.,Tan, Hong-Sheng.,...&Xu, Hong-Xi.(2014).Xanthine Oxidase Inhibitors from Garcinia esculenta Twigs.PLANTA MEDICA,80(18),1721-1726. |
| MLA | Zhu, Lun-Lun,et al."Xanthine Oxidase Inhibitors from Garcinia esculenta Twigs".PLANTA MEDICA 80.18(2014):1721-1726. |
入库方式： OAI收割
来源：上海药物研究所
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