Lithocarpic acids O-S, five homo-cycloartane derivatives from the cupules of Lithocarpus polystachyus
文献类型：期刊论文
| 作者 | Ning, Ruo-nan1; Wang, Hong-min1; Shen, Yu2; Chen, Zhen-hua1; Zhang, Ru-jun1; Leng, Ying2 ; Zhao, Wei-min1
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2014-12-01 |
| 卷号 | 24期号:23页码:5395-5398 |
| ISSN号 | 0960-894X |
| 关键词 | 24-Homo-cycloartane derivative 3,4-seco-Homo-cycloartane derivative Lithocarpus polystachyus Fagaceae 11 beta-HSD1 |
| DOI | 10.1016/j.bmcl.2014.10.036 |
| 文献子类 | Article |
| 英文摘要 | Chemical investigation of the cupules of Lithocarpus polystachyus resulted in the identification of four 3,4-seco-homo-cycloartane and one homo-cycloartane derivatives named lithocarpic acids O-S. Their structures were determined based on extensive 1D/2D NMR, IR, MS spectroscopic analyses and chemical methods. Lithocarpic acid O (1) exhibited inhibitory activities on mouse and human isozymes of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) with IC50 values of 0.49 and 1.1 mu M, respectively. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS关键词 | PHLORHIZIN ; EXTRACT ; REHD |
| 资助项目 | Forestry Industry Research Special Fund for Public Welfare Project[201204612] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000345125500010 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276820]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 天然药物化学研究室 |
| 通讯作者 | Leng, Ying |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ning, Ruo-nan,Wang, Hong-min,Shen, Yu,et al. Lithocarpic acids O-S, five homo-cycloartane derivatives from the cupules of Lithocarpus polystachyus[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(23):5395-5398. |
| APA | Ning, Ruo-nan.,Wang, Hong-min.,Shen, Yu.,Chen, Zhen-hua.,Zhang, Ru-jun.,...&Zhao, Wei-min.(2014).Lithocarpic acids O-S, five homo-cycloartane derivatives from the cupules of Lithocarpus polystachyus.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(23),5395-5398. |
| MLA | Ning, Ruo-nan,et al."Lithocarpic acids O-S, five homo-cycloartane derivatives from the cupules of Lithocarpus polystachyus".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.23(2014):5395-5398. |
入库方式： OAI收割
来源：上海药物研究所
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