Anti-inflammatory secoiridoid glycosides from Gentianella azurea
文献类型：期刊论文
| 作者 | Huang, Yu-jie; Lu, Hui; Yu, Xue-li; Song, Wei-bing; Zhang, Shu-wei; Fen, Lin-yin; Xuan, Li-jiang
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2014-11-15 |
| 卷号 | 24期号:22页码:5260-5264 |
| ISSN号 | 0960-894X |
| 关键词 | Gentianella azurea (Gentianaceae) Secoiridoid glucosides Anti-inflammatory Nitric oxide |
| DOI | 10.1016/j.bmcl.2014.09.055 |
| 文献子类 | Article |
| 英文摘要 | A phytochemical investigation on crude extract of Gentianella azurea led to the isolation of ten new (1-10) and one known (11) secoiridoid glycosides. Their structures were unambiguously elucidated by analysis of 1D and 2D NMR. Compounds 2, 5 and 11 were found to inhibit nitric oxide (NO) production in RAW 264.7 macrophages with IC50 values of 52.78 +/- 8.61, 0.69 +/- 0.23 and 5.18 +/- 1.33, respectively, while indomethacin, the positive control, showed an IC50 value of 1.25 +/- 0.52 mu M. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS关键词 | CONSTITUENTS ; GENTIANACEAE ; MACROPHYLLA ; RATS |
| 资助项目 | National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program', China[2009ZX09301-001] ; National Natural Sciences Foundation of China[30901851] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000343901400026 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276836]  |
| 专题 | 上海中药现代化研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Xuan, Li-jiang |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Yu-jie,Lu, Hui,Yu, Xue-li,et al. Anti-inflammatory secoiridoid glycosides from Gentianella azurea[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(22):5260-5264. |
| APA | Huang, Yu-jie.,Lu, Hui.,Yu, Xue-li.,Song, Wei-bing.,Zhang, Shu-wei.,...&Xuan, Li-jiang.(2014).Anti-inflammatory secoiridoid glycosides from Gentianella azurea.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(22),5260-5264. |
| MLA | Huang, Yu-jie,et al."Anti-inflammatory secoiridoid glycosides from Gentianella azurea".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.22(2014):5260-5264. |
入库方式： OAI收割
来源：上海药物研究所
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