Anti-inflammatory Diterpenoids from the Root Bark of Acanthopanax gracilistylus
文献类型：期刊论文
| 作者 | Wu, Zhi-Yuan1; Zhang, Yi-Bei1; Zhu, Kong-Kai2; Luo, Cheng2 ; Zhang, Jing-Xian1; Cheng, Chun-Ru1; Feng, Rui-Hong1; Yang, Wen-Zhi1; Zeng, Feng1; Wang, Yang1
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2014-11 |
| 卷号 | 77期号:11页码:2342-2351 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/np500125x |
| 文献子类 | Article |
| 英文摘要 | Five new ent-pimarane (1-3, 7, and 8) and three new ent-kaurane diterpenoids (4-6) and a new oleanane triterpene acid (9), together with 22 known compounds, were isolated from the root bark of the medicinal herb Acanthopanax gracilistylus. The structures of 1-9 were established based on the interpretation of high-resolution MS and 1D- and 2D-NMR data. The absolute configurations of 7 and 11 were determined by single-crystal X-ray diffraction and electronic circular dichroism analysis. Compounds 7 and 8 represent rare naturally occurring structures based on the devinyl ent-pimarane skeleton. Compounds 3, 10, 14, 16, and 17 exhibited potent inhibitory effects on the release of interleukin-1 beta (IL-1 beta), interleukin-8 (IL-8), and tumor necrosis factor (TNF-alpha) in lipopolysaccharide-stimulated peripheral blood mononuclear cells. |
| WOS关键词 | ENT-KAURANE DITERPENOIDS ; ARALIA-CORDATA ; IN-VITRO ; TERPENE DERIVATIVES ; AGGREGATION ; LEAVES ; DRUGS ; ACID |
| 资助项目 | Twelfth Five-Year National Science & Technology Support Program[2012BAI29B06] ; Major Projects of Knowledge Innovation Program of the Chinese Academy of Sciences[KSCX2-YW-R-166] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2011ZX09307-002-03] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000345472100003 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276848]  |
| 专题 | 成果转移转化处 中科院受体结构与功能重点实验室 新药研究国家重点实验室 上海中药现代化研究中心 |
| 通讯作者 | Guan, Shu-Hong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Natl Engn Lab Tradit Chinese Med Standardizat Tec, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Zhi-Yuan,Zhang, Yi-Bei,Zhu, Kong-Kai,et al. Anti-inflammatory Diterpenoids from the Root Bark of Acanthopanax gracilistylus[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(11):2342-2351. |
| APA | Wu, Zhi-Yuan.,Zhang, Yi-Bei.,Zhu, Kong-Kai.,Luo, Cheng.,Zhang, Jing-Xian.,...&Guo, De-An.(2014).Anti-inflammatory Diterpenoids from the Root Bark of Acanthopanax gracilistylus.JOURNAL OF NATURAL PRODUCTS,77(11),2342-2351. |
| MLA | Wu, Zhi-Yuan,et al."Anti-inflammatory Diterpenoids from the Root Bark of Acanthopanax gracilistylus".JOURNAL OF NATURAL PRODUCTS 77.11(2014):2342-2351. |
入库方式： OAI收割
来源：上海药物研究所
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