Palladium-Catalyzed Difunctionalization of Alkynes via C-N and S-N Cleavages: A Versatile Approach to Highly Functional Indoles
文献类型：期刊论文
| 作者 | Zhao, Fei; Zhang, Dengyou; Nian, Yong; Zhang, Lei; Yang, Wei; Liu, Hong
|
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2014-10-03 |
| 卷号 | 16期号:19页码:5124-5127 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/ol5024745 |
| 文献子类 | Article |
| 英文摘要 | Palladium catalyzed intramolecular addition of C-N and S-N bond to alkynes with the migration of functional groups has been achieved. A wide range of functional groups including acyl, pyruvoyl, amide, and sulfonyl groups can migrate smoothly and be conveniently introduced at the C-3 postion of indoles in our catalytic system. The operational simplicity and broad substrate scope demonstrate the great potential of this method for the synthesis of highly functional indoles. |
| WOS关键词 | PLATINUM CATALYST ; GOLD ; CYCLIZATION ; ACTIVATION ; ACETALS ; CHLORIDES ; CAPTURE ; AMIDES ; RING |
| 资助项目 | National Natural Science Foundation of China[21021063] ; National Natural Science Foundation of China[91229204] ; National Natural Science Foundation of China[81025017] ; National S&T Major Projects[2012ZX09103101-072] ; National S&T Major Projects[2012ZX09301001-005] ; National S&T Major Projects[2013ZX09507-001] ; National S&T Major Projects[2014ZX09507002-001] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000342719500040 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276875]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Liu, Hong |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Fei,Zhang, Dengyou,Nian, Yong,et al. Palladium-Catalyzed Difunctionalization of Alkynes via C-N and S-N Cleavages: A Versatile Approach to Highly Functional Indoles[J]. ORGANIC LETTERS,2014,16(19):5124-5127. |
| APA | Zhao, Fei,Zhang, Dengyou,Nian, Yong,Zhang, Lei,Yang, Wei,&Liu, Hong.(2014).Palladium-Catalyzed Difunctionalization of Alkynes via C-N and S-N Cleavages: A Versatile Approach to Highly Functional Indoles.ORGANIC LETTERS,16(19),5124-5127. |
| MLA | Zhao, Fei,et al."Palladium-Catalyzed Difunctionalization of Alkynes via C-N and S-N Cleavages: A Versatile Approach to Highly Functional Indoles".ORGANIC LETTERS 16.19(2014):5124-5127. |
入库方式： OAI收割
来源：上海药物研究所
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