Bioactive rearranged limonoids from the Chinese mangrove Xylocarpus granatum Koenig
文献类型：期刊论文
| 作者 | Zhou, Zhen-Fang1; Liu, Hai-Li1; Zhang, Wen2; Kurtan, Tibor3; Mandi, Attila3,4; Benyei, Attila; Li, Jia1 ; Taglialatela-Scafati, Orazio5; Guo, Yue-Wei1
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| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2014-09-16 |
| 卷号 | 70期号:37页码:6444-6449 |
| 关键词 | Xylocarpus granatum Limonoid ECD calculation PTP1B inhibition |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2014.07.027 |
| 文献子类 | Article |
| 英文摘要 | Two new pyridine-containing limonoids, xylogranatopyridines A and B (I and 2) and their formal precursor, prexylogranatopyridine (3) were isolated from the twigs and leaves of the Chinese mangrove, Xylocarpus granatum. Xylogranatopyridine B (2) possesses an unprecedented rearranged B-ring together with a seco-ring A, supporting the biogenetic connection of 1-2 with 3. The chemical structures were elucidated by means of detailed spectroscopic analysis and X-ray single-crystal diffraction. The absolute configurations were assigned using electronic solid-state circular dichroism (ECD) supported by time-dependent density functional theory (TDDFT) ECD calculations and X-ray analysis. Xylogranatopyridine A (1) exhibited a significant inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 22.9 mu M. This is the first report of PTP1B inhibitory activity of limonoids. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS关键词 | NATURAL-PRODUCTS ; A-C ; SEEDS ; TETRANORTRITERPENOIDS ; MOLUCCENSIS ; CHEMISTRY ; SKELETON |
| 资助项目 | National Marine '863' Project[2011AA09070102] ; National Marine '863' Project[2013AA092902] ; Natural Science Foundation of China[21021063] ; Natural Science Foundation of China[81273430] ; Natural Science Foundation of China[31070310] ; SKLDR/SIMM Project[SIMM 1203ZZ-03] ; Syngenta-SIMM-PhD Studentship Project[00000000] ; SKLNM/CPU project[SKLNMKF 201412] ; EU[246987] ; Hungarian National Research Foundation[OTKA K105871] ; Hungarian National Research Foundation[K81701] ; National Information Infrastructure Development Institute[NIIFI 10038] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000340852900009 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276900]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 国家新药筛选中心 |
| 通讯作者 | Taglialatela-Scafati, Orazio |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Second Mil Med Univ, Sch Pharm, Res Ctr Marine Drugs, Shanghai 200433, Peoples R China; 3.Univ Debrecen, Dept Organ Chem, H-4010 Debrecen, Hungary; 4.Univ Debrecen, Fac Sci, Inst Phys Chem, H-4010 Debrecen, Hungary; 5.Univ Naples Federico II, Dipartimento Farm, I-80131 Naples, Italy |
| 推荐引用方式 GB/T 7714 | Zhou, Zhen-Fang,Liu, Hai-Li,Zhang, Wen,et al. Bioactive rearranged limonoids from the Chinese mangrove Xylocarpus granatum Koenig[J]. TETRAHEDRON,2014,70(37):6444-6449. |
| APA | Zhou, Zhen-Fang.,Liu, Hai-Li.,Zhang, Wen.,Kurtan, Tibor.,Mandi, Attila.,...&Guo, Yue-Wei.(2014).Bioactive rearranged limonoids from the Chinese mangrove Xylocarpus granatum Koenig.TETRAHEDRON,70(37),6444-6449. |
| MLA | Zhou, Zhen-Fang,et al."Bioactive rearranged limonoids from the Chinese mangrove Xylocarpus granatum Koenig".TETRAHEDRON 70.37(2014):6444-6449. |
入库方式： OAI收割
来源：上海药物研究所
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