Natural product-based design, synthesis and biological evaluation of anthra[2,1-d]thiazole-6,11-dione derivatives from rhein as novel antitumour agents
文献类型：期刊论文
| 作者 | Liang, Yu-Kun1,2; Yue, Zhi-Zhou1; Li, Jia-Xin2; Tan, Cun2; Miao, Ze-Hong2; Tan, Wen-Fu3; Yang, Chun-Hao2
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| 刊名 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2014-09-12 |
| 卷号 | 84页码:505-515 |
| 关键词 | Rhein analogues Anthra[2,1-d]thiazole-6,11-dione Antitumour SRB assay |
| ISSN号 | 0223-5234 |
| DOI | 10.1016/j.ejmech.2014.07.047 |
| 文献子类 | Article |
| 英文摘要 | Two series of novel 2-substituted 5,7-dihydroxyanthra[2,1-d]thiazole-6,11-dione derivatives from natural rhein were designed, synthesized and evaluated for their antitumour activities against human cancer cell lines A549 and HeLa in vitro. (C) 2014 Elsevier Masson SAS. All rights reserved. |
| WOS关键词 | DRUG DISCOVERY ; EMODIN DERIVATIVES ; EVOLVING ROLE ; DNA-BINDING ; CHEMISTRY ; ANALOGS ; CYTOTOXICITY ; INHIBITORS ; APOPTOSIS ; FUTURE |
| 资助项目 | Chinese Academy of Sciences[00000000] ; SKLDR/SIMM[SIMM1203KF-15] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000341464500046 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276905]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物化学研究室 |
| 通讯作者 | Miao, Ze-Hong |
| 作者单位 | 1.Wuhan Univ Technol, Sch Chem Engn, Dept Pharmaceut Engn, Wuhan 430070, Hunan, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst MateriaMed, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, Yu-Kun,Yue, Zhi-Zhou,Li, Jia-Xin,et al. Natural product-based design, synthesis and biological evaluation of anthra[2,1-d]thiazole-6,11-dione derivatives from rhein as novel antitumour agents[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2014,84:505-515. |
| APA | Liang, Yu-Kun.,Yue, Zhi-Zhou.,Li, Jia-Xin.,Tan, Cun.,Miao, Ze-Hong.,...&Yang, Chun-Hao.(2014).Natural product-based design, synthesis and biological evaluation of anthra[2,1-d]thiazole-6,11-dione derivatives from rhein as novel antitumour agents.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,84,505-515. |
| MLA | Liang, Yu-Kun,et al."Natural product-based design, synthesis and biological evaluation of anthra[2,1-d]thiazole-6,11-dione derivatives from rhein as novel antitumour agents".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 84(2014):505-515. |
入库方式： OAI收割
来源：上海药物研究所
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