Guignardins A-F, spirodioxynaphthalenes from the endophytic fungus Guignardia sp KcF8 as a new class of PTP1B and SIRT1 inhibitors
文献类型：期刊论文
| 作者 | Ai, Wen1,2; Wei, Xiaoyi3; Lin, Xiuping1; Sheng, Li4; Wang, Zhen5 ; Tu, Zhengchao5; Yang, Xianwen1; Zhou, Xuefeng1; Li, Jia4; Liu, Yonghong1
|
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2014-09-02 |
| 卷号 | 70期号:35页码:5806-5814 |
| 关键词 | Spirodioxynaphthalene Kandelia candel Mangrove plant Endophytic fungus Guignardia sp. |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2014.06.041 |
| 文献子类 | Article |
| 英文摘要 | Six new guignardins A-F (1-6) were isolated from the cultures of endophytic fungus Guignardia sp. KcF8 derived of a mangrove plant Kandelia candel, along with three known analogues, palmarumycins C-1 (7), BG1 (8), and JC1 (9). Compounds 2, 3, 7, and 8 showed antimicrobial activities. Compounds 5-7 exhibited significant cytotoxicities against 10 human tumor cell lines. Compound 3 also displayed significant inhibitory activity against human protein tyrosine phosphatase 1B and histone deacetylase silent information regulator T-1 enzymes, two key targets for the treatment of diabetes. This is the first report on the anti-PTP1B and anti-SIRT1 activities of spirodioxynaphthalenes. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS关键词 | PHOSPHATASE ; ACTIVATORS ; DISCOVERY |
| 资助项目 | National Key Basic Research Program of China (973)'s Project[2010CB833800] ; National Key Basic Research Program of China (973)'s Project[2011CB915503] ; National High Technology Research and Development Program (863 Program)[2013AA092901] ; National High Technology Research and Development Program (863 Program)[2012AA092104] ; National Natural Science Foundation of China[31270402] ; National Natural Science Foundation of China[21172230] ; National Natural Science Foundation of China[20902094] ; National Natural Science Foundation of China[41176148] ; National Natural Science Foundation of China[21002110] ; Guangdong Province-CAS Joint Research Program[2011B090300023] ; Guangdong Province-CAS Joint Research Program[2012B091100264] ; Guangdong Marine Economic Development and Innovation of Regional Demonstration Project[GD2012-D01-001] ; Guangdong Marine Economic Development and Innovation of Regional Demonstration Project[GD2012-D01-002] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000340336000055 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276912]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 |
| 通讯作者 | Li, Jia |
| 作者单位 | 1.Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 3.Chinese Acad Sci, South China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Guangzhou 510650, Guangdong, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 5.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ai, Wen,Wei, Xiaoyi,Lin, Xiuping,et al. Guignardins A-F, spirodioxynaphthalenes from the endophytic fungus Guignardia sp KcF8 as a new class of PTP1B and SIRT1 inhibitors[J]. TETRAHEDRON,2014,70(35):5806-5814. |
| APA | Ai, Wen.,Wei, Xiaoyi.,Lin, Xiuping.,Sheng, Li.,Wang, Zhen.,...&Liu, Yonghong.(2014).Guignardins A-F, spirodioxynaphthalenes from the endophytic fungus Guignardia sp KcF8 as a new class of PTP1B and SIRT1 inhibitors.TETRAHEDRON,70(35),5806-5814. |
| MLA | Ai, Wen,et al."Guignardins A-F, spirodioxynaphthalenes from the endophytic fungus Guignardia sp KcF8 as a new class of PTP1B and SIRT1 inhibitors".TETRAHEDRON 70.35(2014):5806-5814. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。