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Polyoxypregnane Steroids from the Stems of Marsdenia tenacissima

文献类型：期刊论文

作者Yao, Sheng1,2,3; To, Kenneth Kin-Wah2,3,4; Wang, Ya-Zhou1,2,3; Yin, Chun2,3,5; Tang, Chunping1,2,3; Chai, Stella2,3,5; Ke, Chang-Qiang1,2,3; Lin, Ge2,3,5; Ye, Yang1,2,3
刊名JOURNAL OF NATURAL PRODUCTS
出版日期2014-09
卷号77期号:9页码:2044-2053
ISSN号0163-3864
DOI10.1021/np500385b
文献子类Article
英文摘要A new polyoxypregnane aglycone, tenacigenin D (1), and seven new C21 steroid glycosides, tenacissimosides D-J (2-8), were isolated from the stems of Marsdenia tenacissima. Their structures were determined by interpretation of their 1D and 2D NMR and other spectroscopic data, as well as by comparison with published values for related known compounds. Compound 1 was found to circumvent P-glycoprotein (P-gp)-mediated multidrug resistance through an inhibitory effect on P-gp with a similar potency to verapamil. In addition, compound 1 potentiated the activity of erlotinib and gefitinib in epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI)-resistant non-small-cell lung cancer cells.
WOS关键词MEDIATED MULTIDRUG-RESISTANCE ; PREGNANE GLYCOSIDES ; REVERSAL ; TRANSPORTERS ; CANCER ; CYTOTOXICITY ; MODULATION ; INHIBITORS ; TOMENTOSA ; DESIGN
资助项目National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program"[2012ZX09301001-001] ; National Natural Science Funds of China[81302657] ; Ministry of Science and Technology[2010DFA30980] ; Chinese Academy of Sciences[KSZD-EW-Z-004-01] ; Shanghai Commission of Science and Technology[11DZ1970700] ; Shanghai Commission of Science and Technology[12JC1410300] ; Health and Medical Research Fund (HHSRF Project) from the Food and Health Bureau, HKSAR[08090481] ; Chinese University of Hong Kong Direct Grant[2041448]
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000342477900009
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/276917]  
专题天然药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Lin, Ge
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res & Nat Prod, Dept Chem, Shanghai 201203, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, Joint Res Lab Promoting Globalizat Tradit Chinese, Shanghai 201203, Peoples R China;
3.Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China;
4.Chinese Univ Hong Kong, Fac Med, Sch Pharm, Hong Kong, Hong Kong, Peoples R China;
5.Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714		 Yao, Sheng,To, Kenneth Kin-Wah,Wang, Ya-Zhou,et al. Polyoxypregnane Steroids from the Stems of Marsdenia tenacissima[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(9):2044-2053.
APA Yao, Sheng.,To, Kenneth Kin-Wah.,Wang, Ya-Zhou.,Yin, Chun.,Tang, Chunping.,...&Ye, Yang.(2014).Polyoxypregnane Steroids from the Stems of Marsdenia tenacissima.JOURNAL OF NATURAL PRODUCTS,77(9),2044-2053.
MLA Yao, Sheng,et al."Polyoxypregnane Steroids from the Stems of Marsdenia tenacissima".JOURNAL OF NATURAL PRODUCTS 77.9(2014):2044-2053.

入库方式： OAI收割

来源：上海药物研究所

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