Cardiac glycosides from the bark of Antiaris toxicaria
文献类型：期刊论文
| 作者 | Li, Xiao-San1; Hu, Meng-Jie2; Liu, Jie2; Liu, Qian1; Huang, Zhi-Xing1; Li, Shun-Lin3; Hao, Xiao-Jiang3; Zhang, Xiao-Kun2; Yao, Xin-Sheng1; Tang, Jin-Shan1,4 |
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2014-09 |
| 卷号 | 97页码:71-77 |
| 关键词 | Antiaris toxicaria Chemical constituents Cardiac glycoside Cytotoxicity Expression of Nur77 |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2014.05.013 |
| 文献子类 | Article |
| 英文摘要 | Five new cardiac glycosides (1-5, namely antiaroside Y-ZC) together with 19 known compounds were obtained from the bark of Antiaris toxicaria. Their chemical structures were determined by IR, HR-ESI-MS, 1D and 2D NMR (HSQC, H-1-H-1 COSY, HMBC, ROESY). The absolute configuration of sugar unit was defined by acid hydrolysis and appropriate derivatization. Compound 1 was rare 5 beta-H-10 beta-H-19-nor-cardenolide, which might derive from decarboxylative derivative of 19-COOH cardenolide. The inhibitory effects of cardiac glycosides 1-11 on the viability of NIH-H460 lung cancer cells and their induction of Nur77 expression were evaluated and preliminary structure-activity relationship (SAR) was also discussed. (c) 2014 Elsevier B.V. All rights reserved. |
| WOS关键词 | BREAST-CANCER ; DIGITALIS ; CARDENOLIDES ; ACTIVATION ; CARCINOMA ; DIGITOXIN ; CELLS |
| 资助项目 | National Natural Science Foundation of China[81001373] ; National Natural Science Foundation of China[91129302] ; State Key Laboratory of Drug Research[SIMM1403KF-15] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000341346400009 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276922]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Tang, Jin-Shan |
| 作者单位 | 1.Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China; 2.Xiamen Univ, Sch Pharmaceut Sci, Xiamen 361005, Peoples R China; 3.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650204, Peoples R China; 4.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xiao-San,Hu, Meng-Jie,Liu, Jie,et al. Cardiac glycosides from the bark of Antiaris toxicaria[J]. FITOTERAPIA,2014,97:71-77. |
| APA | Li, Xiao-San.,Hu, Meng-Jie.,Liu, Jie.,Liu, Qian.,Huang, Zhi-Xing.,...&Tang, Jin-Shan.(2014).Cardiac glycosides from the bark of Antiaris toxicaria.FITOTERAPIA,97,71-77. |
| MLA | Li, Xiao-San,et al."Cardiac glycosides from the bark of Antiaris toxicaria".FITOTERAPIA 97(2014):71-77. |
入库方式： OAI收割
来源：上海药物研究所
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