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Naturally Occurring Homoisoflavonoids and Their Pharmacological Activities

文献类型：期刊论文

作者Lin, Li-Gen1; Liu, Qian-Yu1; Ye, Yang2
刊名PLANTA MEDICA
出版日期2014-08
卷号80期号:13页码:1053-1066
关键词homoisoflavonoids phytochemistry biosynthesis pharmacological activities
ISSN号0032-0943
DOI10.1055/s-0034-1383026
文献子类Review
英文摘要Homoisoflavonoids, a special subclass of flavonoids, are rarely found in nature, mainly existing in Fabaceae and Asparagaceae families and being less common in Polygonaceae, Portulacaceae, Orchidaceae, and Gentianaceae families. Until now, approximately 240 natural occurring homoisoflavonoids have been identified from roots, barks, heartwood, bulbs, leaves, and seeds of the plants from the above mentioned families, which have often been used in traditional medicine. Homoisoflavonoids have been reported with a broad range of bioactivities, including anti-microbial, anti-mutagenic, anti-oxidant, immunomodulatory, anti-diabetic, cytotoxic, anti-angiogenic, vasorelaxant, and anti-inflammatory effects. To organize this review, the homoisoflavonoids were classified into five groups based on their structures: sappanin-type (I), scillascillin-type (II), brazilin-type (III), caesalpin-type (IV), and protosappanin-type (V). The structures of natural occurring homoisoflavonoids are described, and their proposed biosynthetic pathway and recent pharmacological studies are discussed. The main purpose of this review is to provide a comprehensive and up-to-date state of knowledge from phytochemical and pharmacological studies performed on homoisoflavonoids during the past decades. Homoisoflavonoids might have a large potential for further investigations of their bioactivities in order to identify important leads.
WOS关键词CAESALPINIA-SAPPAN L ; TYROSINE KINASE INHIBITORS ; NERVOSA-SUBSP-RIGIDIFOLIA ; JAPONICUS KER-GAWLER ; OPHIOPOGON-JAPONICUS ; ANTIINFLAMMATORY ACTIVITY ; POLYGONATUM-ODORATUM ; MUSCARI-RACEMOSUM ; SCILLA-NERVOSA ; HAEMATOXYLON-CAMPECHIANUM
资助项目Research Fund of the University of Macau[SRG2013-00038-ICMS-QRCM] ; Research Fund of the University of Macau[MYRG2014-00020-ICMS-QRCM] ; Science and Technology Development Fund of Macau[120/2013/A3]
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
语种英语
WOS记录号WOS:000341581600001
出版者GEORG THIEME VERLAG KG
源URL[http://119.78.100.183/handle/2S10ELR8/276953]  
专题天然药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Lin, Li-Gen
作者单位1.Univ Macau, State Key Lab Qual Res Chinese Med, Inst Chinese Med Sci, Taipa 999078, Macau, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China
推荐引用方式
GB/T 7714		 Lin, Li-Gen,Liu, Qian-Yu,Ye, Yang. Naturally Occurring Homoisoflavonoids and Their Pharmacological Activities[J]. PLANTA MEDICA,2014,80(13):1053-1066.
APA Lin, Li-Gen,Liu, Qian-Yu,&Ye, Yang.(2014).Naturally Occurring Homoisoflavonoids and Their Pharmacological Activities.PLANTA MEDICA,80(13),1053-1066.
MLA Lin, Li-Gen,et al."Naturally Occurring Homoisoflavonoids and Their Pharmacological Activities".PLANTA MEDICA 80.13(2014):1053-1066.

入库方式： OAI收割

来源：上海药物研究所

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