Lithocarpic Acids A-N, 3,4-seco-Cycloartane Derivatives from the Cupules of Lithocarpus polystachyus
文献类型：期刊论文
| 作者 | Wang, Hongmin1; Ning, Ruonan1; Shen, Yu2; Chen, Zhenhua1; Li, Jinlong1; Zhang, Rujun1; Leng, Ying2 ; Zhao, Weimin1
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2014-08 |
| 卷号 | 77期号:8页码:1910-1920 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/np500379f |
| 文献子类 | Article |
| 英文摘要 | Fourteen new 3,4-seco-cycloartane-type triterpenes, lithocarpic acids A-N (1-14), together with one known compound, coccinetane E (15), were identified from the cupules of Lithocarpus polystachyus. The structures of 1-14 were determined by spectroscopic data analysis and chemical methods, and the absolute configurations of 1 and 4 were defined unequivocally by X-ray crystallography using Cu K alpha radiation. Compounds 1-15 are the first examples of 3,4-seco-cycloartane derivatives isolated from the genus Lithocarpus. Among them, compounds 1 and 2, 9 and 10, and 11 and 12 were found to be three pairs of C-24 epimers, while compounds 7 and 8 represent the first examples of 3,4-seco-norcycloartane-type triterpenes. Compound 1, as the major component of the plant extract, showed potent antibacterial activity against Micrococcus luteus and Bacillus subtilis, with MIC values of 3.1 and 6.3 mu g/mL, respectively, as well as inhibitory activity against human and mouse 11 beta-hydroxysteroid dehydrogenase type 1, with IC50 values of 1.9 and 0.24 mu M, respectively. |
| WOS关键词 | HONG-KONG ; TRITERPENOIDS ; RATS ; LEAVES ; IDENTIFICATION ; 11-BETA-HSD1 ; PHLORHIZIN ; INHIBITORS ; EXTRACT ; REHD. |
| 资助项目 | Forestry Industry Research Special Fund for Public Welfare Project[201204612] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000340861800020 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276956]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 天然药物化学研究室 |
| 通讯作者 | Leng, Ying |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Hongmin,Ning, Ruonan,Shen, Yu,et al. Lithocarpic Acids A-N, 3,4-seco-Cycloartane Derivatives from the Cupules of Lithocarpus polystachyus[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(8):1910-1920. |
| APA | Wang, Hongmin.,Ning, Ruonan.,Shen, Yu.,Chen, Zhenhua.,Li, Jinlong.,...&Zhao, Weimin.(2014).Lithocarpic Acids A-N, 3,4-seco-Cycloartane Derivatives from the Cupules of Lithocarpus polystachyus.JOURNAL OF NATURAL PRODUCTS,77(8),1910-1920. |
| MLA | Wang, Hongmin,et al."Lithocarpic Acids A-N, 3,4-seco-Cycloartane Derivatives from the Cupules of Lithocarpus polystachyus".JOURNAL OF NATURAL PRODUCTS 77.8(2014):1910-1920. |
入库方式： OAI收割
来源：上海药物研究所
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