Involvement of transcription factor XBP1s in the resistance of HDAC6 inhibitor Tubastatin A to superoxidation via acetylation-mediated proteasomal degradation
文献类型：期刊论文
| 作者 | Zhang, Yue1,2; Liu, Chang-mei1,2; Cao, Xian-cao1,2; Zang, Yi2 ; Zhou, Yu-bo2; Li, Jia1,2
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| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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| 出版日期 | 2014-07-18 |
| 卷号 | 450期号:1页码:433-439 |
| 关键词 | Tubastatin A HDAC6 XBP1s Oxidative stress Transcription regulation |
| ISSN号 | 0006-291X |
| DOI | 10.1016/j.bbrc.2014.05.134 |
| 文献子类 | Article |
| 英文摘要 | HDAC6 is a major cytoplasmic deacetylase. XBP1s is a basic-region leucine zipper (bZIP) transcriptional factor. Despite their mutual involvement in the anti-oxidative process, there are no reports about their inter-protein interactions so far. Here we identified a direct link between HDAC6 inhibition and XBP1s transcription activity in anti-oxidative damage. We showed that the specific HDAC6 inhibitor Tubastatin A could up-regulate XBP1s transcriptional activity, thereby increasing anti-oxidative genes expression. Moreover, knock down of XBP1s could significantly abolish the cell growth protection afforded by Tubastatin A. We hypothesize that Tubastatin A acts to increase XBP1s protein levels that are dependent on its HDAC6 deacetylase inhibition via a mechanism involving acetylation-mediated proteasomal degradation, providing novel mechanistic insight into the anti-oxidative effects of HDAC6 inhibition. (C) 2014 Elsevier Inc. All rights reserved. |
| WOS关键词 | UNFOLDED PROTEIN RESPONSE ; HISTONE DEACETYLASE ; LYSINE ACETYLATION ; OXIDATIVE STRESS ; RECEPTOR ; DIFFERENTIATION ; ACTIVATION ; STABILITY ; APOPTOSIS ; MOTILITY |
| 资助项目 | National Natural Science Foundation of China[91029716] ; National Natural Science Foundation of China[81125023] ; National Natural Science Foundation of China[81173033] ; National Natural Science Foundation of China[81270942] ; National Major Scientific and Technological Special Project for "significant new drugs creation"[2012ZX09301001-004] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000343641000071 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276984]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhou, Yu-bo |
| 作者单位 | 1.E China Normal Univ, Sch Life Sci, Shanghai 200062, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yue,Liu, Chang-mei,Cao, Xian-cao,et al. Involvement of transcription factor XBP1s in the resistance of HDAC6 inhibitor Tubastatin A to superoxidation via acetylation-mediated proteasomal degradation[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014,450(1):433-439. |
| APA | Zhang, Yue,Liu, Chang-mei,Cao, Xian-cao,Zang, Yi,Zhou, Yu-bo,&Li, Jia.(2014).Involvement of transcription factor XBP1s in the resistance of HDAC6 inhibitor Tubastatin A to superoxidation via acetylation-mediated proteasomal degradation.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,450(1),433-439. |
| MLA | Zhang, Yue,et al."Involvement of transcription factor XBP1s in the resistance of HDAC6 inhibitor Tubastatin A to superoxidation via acetylation-mediated proteasomal degradation".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 450.1(2014):433-439. |
入库方式： OAI收割
来源：上海药物研究所
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