Microwave Assisted Tandem Heck-Sonogashira Reactions of N,N-Di-Boc-Protected 6-Amino-5-iodo-2-methyl Pyrimidin-4-ol in An Efficient Approach to Functionalized Pyrido[2,3-d]Pyrimidines
文献类型：期刊论文
| 作者 | Liu, Yang1; Jin, Shiyu1; Wang, Zi2; Song, Linhua2; Hua, Youhong1 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2014-07-04 |
| 卷号 | 16期号:13页码:3524-3527 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/ol501459e |
| 文献子类 | Article |
| 英文摘要 | A microwave assisted tandem Heck-Sonogashira cross-coupling reaction between 6-N,N-di-Boc-amino-5-iodo-2-methyl pyrimidin-4-ol and various aryl alkynyl substrates has been developed. This process generates novel 5-enynyl substituted pyrimidines, which can be transformed to novel functionalized pyrido[2,3-d]pyrimidines by way of a silver catalyzed cyclization reaction. |
| WOS关键词 | ANTIBACTERIAL ACTIVITY ; COUPLING REACTIONS ; ARYL IODIDES ; DERIVATIVES ; POTENT ; INHIBITORS ; IDENTIFICATION ; ALKYNYLATION ; ANTAGONISTS ; ALKYNES |
| 资助项目 | National Natural Science Foundation of China[81225022] ; SA-SIBS Scholarship Program[00000000] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000340808000027 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276991]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Hua, Youhong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.China Univ Petr East China, Coll Sci, Qingdao 266580, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yang,Jin, Shiyu,Wang, Zi,et al. Microwave Assisted Tandem Heck-Sonogashira Reactions of N,N-Di-Boc-Protected 6-Amino-5-iodo-2-methyl Pyrimidin-4-ol in An Efficient Approach to Functionalized Pyrido[2,3-d]Pyrimidines[J]. ORGANIC LETTERS,2014,16(13):3524-3527. |
| APA | Liu, Yang,Jin, Shiyu,Wang, Zi,Song, Linhua,&Hua, Youhong.(2014).Microwave Assisted Tandem Heck-Sonogashira Reactions of N,N-Di-Boc-Protected 6-Amino-5-iodo-2-methyl Pyrimidin-4-ol in An Efficient Approach to Functionalized Pyrido[2,3-d]Pyrimidines.ORGANIC LETTERS,16(13),3524-3527. |
| MLA | Liu, Yang,et al."Microwave Assisted Tandem Heck-Sonogashira Reactions of N,N-Di-Boc-Protected 6-Amino-5-iodo-2-methyl Pyrimidin-4-ol in An Efficient Approach to Functionalized Pyrido[2,3-d]Pyrimidines".ORGANIC LETTERS 16.13(2014):3524-3527. |
入库方式： OAI收割
来源：上海药物研究所
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