Hainanerectamines A-C, Alkaloids from the Hainan Sponge Hyrtios erecta
文献类型：期刊论文
| 作者 | He, Wen-Fei1,2; Xue, Duo-Qing2; Yao, Li-Gong2; Li, Jing-Ya2 ; Li, Jia2; Guo, Yue-Wei2
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| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2014-07 |
| 卷号 | 12期号:7页码:3982-3993 |
| 关键词 | sponge Hyrtios erecta Thorectidae hainanerectamines indole beta-carboline Aurora A |
| ISSN号 | 1660-3397 |
| DOI | 10.3390/md12073982 |
| 文献子类 | Article |
| 英文摘要 | Two new indole alkaloids, hainanerectamines A (1) and B (2), and one new beta-carboline alkaloids, hainanerectamines C (4), along with five known related alkaloids (3, 5-8), have been isolated from the Hainan marine sponge Hyrtios erecta. The structures of new compounds 1, 2 and 4 were determined by detailed analysis of their 1D and 2D NMR spectra and by comparison of their spectroscopic data with those of related model compounds. Compounds 2-4 exhibited moderate inhibitory activity against Aurora A, a member of serine/threonine kinase family involving in the regulation of cell division and a new target in cancer treatment, with IC50 values of 24.5, 13.6, and 18.6 mu g/mL, respectively. |
| WOS关键词 | SECRETORY PHOSPHOLIPASE A(2) ; AURORA KINASE INHIBITORS ; MARINE SPONGE ; INDOLE ALKALOIDS ; GENUS HYRTIOS ; ALTOHYRTIN-A ; SESTERTERPENES ; CANCER ; MACROLIDE ; DRUGS |
| 资助项目 | National Marine 863 Projects[2011AA09070102] ; National Marine 863 Projects[SS2013AA090202] ; Natural Science Foundation of China[41306130] ; Natural Science Foundation of China[21072204] ; Natural Science Foundation of China[81273430] ; Natural Science Foundation of China[20721003] ; State Key Laboratory of Drug Research-SIMM[SIMM1203KF-12] ; China Postdotoral Science Foundation[2012M520956] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000339989300012 |
| 出版者 | MDPI AG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276997]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 天然药物化学研究室 |
| 通讯作者 | Guo, Yue-Wei |
| 作者单位 | 1.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Wen-Fei,Xue, Duo-Qing,Yao, Li-Gong,et al. Hainanerectamines A-C, Alkaloids from the Hainan Sponge Hyrtios erecta[J]. MARINE DRUGS,2014,12(7):3982-3993. |
| APA | He, Wen-Fei,Xue, Duo-Qing,Yao, Li-Gong,Li, Jing-Ya,Li, Jia,&Guo, Yue-Wei.(2014).Hainanerectamines A-C, Alkaloids from the Hainan Sponge Hyrtios erecta.MARINE DRUGS,12(7),3982-3993. |
| MLA | He, Wen-Fei,et al."Hainanerectamines A-C, Alkaloids from the Hainan Sponge Hyrtios erecta".MARINE DRUGS 12.7(2014):3982-3993. |
入库方式： OAI收割
来源：上海药物研究所
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