Benzimidazole derivative, BM601, a novel inhibitor of hepatitis B virus and HBsAg secretion
文献类型：期刊论文
| 作者 | Xu, Yi-Bin1; Yang, Li1; Wang, Gui-Feng1 ; Tong, Xian-Kun1; Wang, Ya-Juan1; Yu, Ye1; Jing, Jing-Feng1; Feng, Chun-Lan1; He, Pei-Lan1; Lu, Wei2
|
| 刊名 | ANTIVIRAL RESEARCH
 |
| 出版日期 | 2014-07 |
| 卷号 | 107页码:6-15 |
| 关键词 | Anti-hepatitis B virus compound Benzimidazole derivative Secretion inhibitor |
| ISSN号 | 0166-3542 |
| DOI | 10.1016/j.antiviral.2014.04.002 |
| 文献子类 | Article |
| 英文摘要 | Hepatitis B virus (HBV) belongs to the Hepadnaviridae family. HBsAg, greatly outnumbered mature virion, has been mysterious since the discovery of HBV. A novel benzimidazole derivative, BM601, is identified inhibiting the secretion of HBV virions and HBsAg, with 50% effective concentration of 0.6 mu M and 1.5 mu M, as well as 50% cytotoxicity concentration of 24.5 mu M. It has no effect on transcription, protein production, nucleocapsid formation or intracellular HBV DNA synthesis. Immunofluorescence analysis suggests that BM601 might inhibit virion and HBsAg secretion by interfering surface protein aggregation in trans Golgi apparatus. Furthermore, BM601 does not trigger cellular stress response or affect HBeAg or host protein secretion. We hypothesize that BM601 is a secretion inhibitor functioning at the level of virion and HBsAg secretion pathway. (C) 2014 Elsevier B.V. All rights reserved. |
| WOS关键词 | SURFACE-ANTIGEN SECRETION ; AMINO-ACID SUBSTITUTIONS ; HEPATOCELLULAR-CARCINOMA ; IN-VITRO ; ANTIFUNGAL ACTIVITIES ; ANTITUMOR-ACTIVITY ; ENVELOPE PROTEIN ; GENE-EXPRESSION ; TRANSGENIC MICE ; CELLS |
| 资助项目 | National Program on Key Basic Research Project (973 Program)[2013CB911104] |
| WOS研究方向 | Pharmacology & Pharmacy ; Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000338412500002 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277008]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Lu, Wei |
| 作者单位 | 1.Chinese Acad Sci, Lab Immunopharmacol, State Key Lab Drug Res, Shanghai Inst Mat Med, Beijing 100864, Peoples R China; 2.E China Normal Univ, Inst Drug Discovery & Dev, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Shanghai 200062, Peoples R China; 3.Shanghai Univ Tradit Chinese Med, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Yi-Bin,Yang, Li,Wang, Gui-Feng,et al. Benzimidazole derivative, BM601, a novel inhibitor of hepatitis B virus and HBsAg secretion[J]. ANTIVIRAL RESEARCH,2014,107:6-15. |
| APA | Xu, Yi-Bin.,Yang, Li.,Wang, Gui-Feng.,Tong, Xian-Kun.,Wang, Ya-Juan.,...&Zuo, Jian-Ping.(2014).Benzimidazole derivative, BM601, a novel inhibitor of hepatitis B virus and HBsAg secretion.ANTIVIRAL RESEARCH,107,6-15. |
| MLA | Xu, Yi-Bin,et al."Benzimidazole derivative, BM601, a novel inhibitor of hepatitis B virus and HBsAg secretion".ANTIVIRAL RESEARCH 107(2014):6-15. |
入库方式： OAI收割
来源：上海药物研究所
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