A seco-laurane sesquiterpene and related laurane derivatives from the red alga Laurencia okamurai Yamada
文献类型：期刊论文
| 作者 | Yu, Xiao-Qing1; He, Wen-Fei2; Liu, Ding-Quan1; Feng, Mei-Tang1; Fang, Yi1; Wang, Bin1; Feng, Li-Hua1; Guo, Yue-Wei2 ; Mao, Shui-Chun1,3
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| 刊名 | PHYTOCHEMISTRY
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| 出版日期 | 2014-07 |
| 卷号 | 103页码:162-170 |
| 关键词 | Laurencia okamurai Laurencia Rhodomelaceae seco-Laurokamurane sesquiterpene Laurokamurane sesquiterpene Laurane sesquiterpene Bisabolane sesquiterpene Antifungal activity Cytotoxicity |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2014.03.021 |
| 文献子类 | Article |
| 英文摘要 | A ring-cleaved sesquiterpene, named seco-laurokamurone, four laurane-type sesquiterpenes, laurepoxyene, 3 beta-hydroperoxyaplysin, 3 alpha-hydroperoxy-3-epiaplysin, and 8,10-dibromoisoaplysin, one laurokamurane-type sesquiterpene, laurokamurene D, and one bisabolane-type sesquiterpene, (5S)-5acetoxy-beta-bisabolene, have been isolated from a re-collection of the red alga Laurencia okamurai Yamada, together with six other known sesquiterpenes. Their structures, including relative configuration, were elucidated by detailed analysis of spectroscopic data, and by comparison with data for related known compounds. In addition, on the basis of chemical conversions, degradation results, and biogenetic considerations, the absolute configurations of several of these compounds were also tentatively proposed. seco-Laurokamurone possesses an unprecedented carbon skeleton, formed from an oxidative cleavage of the laurokamurane skeleton, and laurokamurene D represents the fourth example of a laurokamurane-type sesquiterpene from a natural source. The in vitro antifungal activity of many of these compounds was evaluated against four fungi (Clyptococcus neoformans, Candida glabrata, Trichophyton rubrum, and Aspergillus fumigatus), as well as assessing cytotoxicity against HL-60 and A-549 human cancer cell lines. The compounds studied displayed moderate activities, relative to controls. (c) 2014 Elsevier Ltd. All rights reserved. |
| WOS关键词 | HALOGENATED METABOLITES ; ABSOLUTE-CONFIGURATION ; OBTUSA ; (-)-APLYSIN ; CUPARENE ; (-)-DEBROMOAPLYSIN ; ACETOGENINS ; CERAMIALES ; COMPOSITA ; ETHER |
| 资助项目 | National Natural Science Foundation of China[20862013] ; National Natural Science Foundation of China[81001397] ; National Natural Science Foundation of China[21162016] ; Natural Science Foundation of Jiangxi Province, China[2010GQY0217] ; State Key Laboratory of Drug Research-SIMM[SIMM1203KF-12] ; China Postdotoral Science Foundation[2012M520956] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000337777800020 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277015]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Mao, Shui-Chun |
| 作者单位 | 1.Nanchang Univ, Sch Pharm, Nanchang 330006, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Nanchang Univ, Inst Translat Med, Nanchang 330031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Xiao-Qing,He, Wen-Fei,Liu, Ding-Quan,et al. A seco-laurane sesquiterpene and related laurane derivatives from the red alga Laurencia okamurai Yamada[J]. PHYTOCHEMISTRY,2014,103:162-170. |
| APA | Yu, Xiao-Qing.,He, Wen-Fei.,Liu, Ding-Quan.,Feng, Mei-Tang.,Fang, Yi.,...&Mao, Shui-Chun.(2014).A seco-laurane sesquiterpene and related laurane derivatives from the red alga Laurencia okamurai Yamada.PHYTOCHEMISTRY,103,162-170. |
| MLA | Yu, Xiao-Qing,et al."A seco-laurane sesquiterpene and related laurane derivatives from the red alga Laurencia okamurai Yamada".PHYTOCHEMISTRY 103(2014):162-170. |
入库方式： OAI收割
来源：上海药物研究所
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