Synthesis of isoquinolinone-based tricycles as novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors
文献类型：期刊论文
| 作者 | Chen, Jianyang1; Peng, Haixia1; He, Jinxue2; Huan, Xiajuan2; Miao, Zehong2; Yang, Chunhao1
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2014-06-15 |
| 卷号 | 24期号:12页码:2669-2673 |
| 关键词 | Isoquinolinone-based tricycles PARP-1 inhibitors Antitumor |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2014.04.061 |
| 文献子类 | Article |
| 英文摘要 | The isoquinolinone-based tricyclic compounds were designed and synthesized. Preliminary biological study of these compounds provided potent compounds 17a, 33b, 33c, 33d, and 33g with low nanomolar IC(50)s against PARP-1 enzyme. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS关键词 | CANCER ; REPAIR ; CELLS ; THERAPY ; DESIGN |
| 资助项目 | National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program''[2012ZX09301001-001] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program''[2012ZX09103101-071] ; National Natural Science Foundation of China[21072205] ; National Natural Science Foundation of China[81025020] ; [SIMM1203ZZ-0103] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000335921200015 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277024]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物化学研究室 |
| 通讯作者 | Miao, Zehong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Dept Med Chem, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Jianyang,Peng, Haixia,He, Jinxue,et al. Synthesis of isoquinolinone-based tricycles as novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(12):2669-2673. |
| APA | Chen, Jianyang,Peng, Haixia,He, Jinxue,Huan, Xiajuan,Miao, Zehong,&Yang, Chunhao.(2014).Synthesis of isoquinolinone-based tricycles as novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(12),2669-2673. |
| MLA | Chen, Jianyang,et al."Synthesis of isoquinolinone-based tricycles as novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.12(2014):2669-2673. |
入库方式： OAI收割
来源：上海药物研究所
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