Ivorenoids A-F: limonoids from Khaya ivorensis
文献类型：期刊论文
| 作者 | Wu, Wen-Bin; Zhang, Hua; Liu, Hong-Chun ; Dong, Shi-Hui; Wu, Yan; Ding, Jian; Yue, Jian-Min
|
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2014-06-03 |
| 卷号 | 70期号:22页码:3570-3575 |
| 关键词 | Khaya ivorensis Limonoid Ivorenoid Cytotoxicity |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2014.04.007 |
| 文献子类 | Article |
| 英文摘要 | Six new limonoids, ivorenoids A-F (1-6), along with ten known analogues, were isolated from an ethanolic extract of the stems of Khaya ivorensis. Their structures were elucidated on the basis of spectroscopic analyses. Compounds 1 and 2 possessed a rare rearranged skeleton of khayanolides and a unique gamma-lactone (C-16/C-8) replacing the common and characteristic delta-lactone D-ring (C-16/C-17) of limonoids. A mechanism of the interesting deuteration of H-2 and H-15 beta of 1, and H-15 beta of the solvent CD3OD due to the keto enol tautomerism was demonstrated. Compounds 3 and 6 showed moderate activity against HL-60 cell line with IC50 values of 15.3 and 17.5 mu M, respectively. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS关键词 | STEM BARK ; SENEGALENSIS ; GRANDIFOLIOLA ; MACROLIDE ; MELIACEAE |
| 资助项目 | National Natural Science Foundation[81273398] ; Ministry of Science and Technology of the People's Republic of China[2012CB721105] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000336868200005 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277034]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yue, Jian-Min |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Wen-Bin,Zhang, Hua,Liu, Hong-Chun,et al. Ivorenoids A-F: limonoids from Khaya ivorensis[J]. TETRAHEDRON,2014,70(22):3570-3575. |
| APA | Wu, Wen-Bin.,Zhang, Hua.,Liu, Hong-Chun.,Dong, Shi-Hui.,Wu, Yan.,...&Yue, Jian-Min.(2014).Ivorenoids A-F: limonoids from Khaya ivorensis.TETRAHEDRON,70(22),3570-3575. |
| MLA | Wu, Wen-Bin,et al."Ivorenoids A-F: limonoids from Khaya ivorensis".TETRAHEDRON 70.22(2014):3570-3575. |
入库方式： OAI收割
来源：上海药物研究所
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