中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Ivorenoids A-F: limonoids from Khaya ivorensis

文献类型:期刊论文

作者Wu, Wen-Bin; Zhang, Hua; Liu, Hong-Chun; Dong, Shi-Hui; Wu, Yan; Ding, Jian; Yue, Jian-Min
刊名TETRAHEDRON
出版日期2014-06-03
卷号70期号:22页码:3570-3575
关键词Khaya ivorensis Limonoid Ivorenoid Cytotoxicity
ISSN号0040-4020
DOI10.1016/j.tet.2014.04.007
文献子类Article
英文摘要Six new limonoids, ivorenoids A-F (1-6), along with ten known analogues, were isolated from an ethanolic extract of the stems of Khaya ivorensis. Their structures were elucidated on the basis of spectroscopic analyses. Compounds 1 and 2 possessed a rare rearranged skeleton of khayanolides and a unique gamma-lactone (C-16/C-8) replacing the common and characteristic delta-lactone D-ring (C-16/C-17) of limonoids. A mechanism of the interesting deuteration of H-2 and H-15 beta of 1, and H-15 beta of the solvent CD3OD due to the keto enol tautomerism was demonstrated. Compounds 3 and 6 showed moderate activity against HL-60 cell line with IC50 values of 15.3 and 17.5 mu M, respectively. (C) 2014 Elsevier Ltd. All rights reserved.
WOS关键词STEM BARK ; SENEGALENSIS ; GRANDIFOLIOLA ; MACROLIDE ; MELIACEAE
资助项目National Natural Science Foundation[81273398] ; Ministry of Science and Technology of the People's Republic of China[2012CB721105]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000336868200005
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/277034]  
专题天然药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Yue, Jian-Min
作者单位Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714
Wu, Wen-Bin,Zhang, Hua,Liu, Hong-Chun,et al. Ivorenoids A-F: limonoids from Khaya ivorensis[J]. TETRAHEDRON,2014,70(22):3570-3575.
APA Wu, Wen-Bin.,Zhang, Hua.,Liu, Hong-Chun.,Dong, Shi-Hui.,Wu, Yan.,...&Yue, Jian-Min.(2014).Ivorenoids A-F: limonoids from Khaya ivorensis.TETRAHEDRON,70(22),3570-3575.
MLA Wu, Wen-Bin,et al."Ivorenoids A-F: limonoids from Khaya ivorensis".TETRAHEDRON 70.22(2014):3570-3575.

入库方式: OAI收割

来源:上海药物研究所

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