JG6, a novel marine-derived oligosaccharide, suppresses breast cancer metastasis via binding to cofilin
文献类型：期刊论文
| 作者 | Huang, Xun ; Sun, Danni; Pan, Qiuming; Wen, Weiwei; Chen, Yi; Xin, Xianliang; Huang, Min; Ding, Jian; Geng, Meiyu
|
| 刊名 | ONCOTARGET
 |
| 出版日期 | 2014-06 |
| 卷号 | 5期号:11页码:3568-3578 |
| 关键词 | JG6 cofilin actin migration metastasis |
| ISSN号 | 1949-2553 |
| DOI | 10.18632/oncotarget.1959 |
| 文献子类 | Article |
| 英文摘要 | Cofilin, an actin-binding protein which disassembles actin filaments, plays an important role in invasion and metastasis. Here, we discover that JG6, an oligomannurarate sulfate, binds to cofilin, suppresses the migration of human breast cancer cells and cancer metastasis in breast cancer xenograft model. Mechanistically, JG6 occupies actin-binding sites of cofilin, thereby disrupting cofilin modulated actin turnover. Our results highlight the significance of cofilin in cancer and suggest JG6, a cofilin inhibitor, to treat metastatic cancer. |
| WOS关键词 | ACTIN DYNAMICS ; CELL-MIGRATION ; IN-VITRO ; F-ACTIN ; MOTILITY ; POLYMERIZATION ; ADF/COFILIN ; JASPLAKINOLIDE ; CYTOSKELETON ; CHEMOTAXIS |
| 资助项目 | National Natural Science Foundation of China[81102461] ; National Natural Science Foundation of China[81302791] ; National S&T Major Projects[2012ZX09301001-007] ; National S&T Major Projects[2012ZX09301001-001] |
| WOS研究方向 | Oncology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000339054500013 |
| 出版者 | IMPACT JOURNALS LLC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277039]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Geng, Meiyu |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Xun,Sun, Danni,Pan, Qiuming,et al. JG6, a novel marine-derived oligosaccharide, suppresses breast cancer metastasis via binding to cofilin[J]. ONCOTARGET,2014,5(11):3568-3578. |
| APA | Huang, Xun.,Sun, Danni.,Pan, Qiuming.,Wen, Weiwei.,Chen, Yi.,...&Geng, Meiyu.(2014).JG6, a novel marine-derived oligosaccharide, suppresses breast cancer metastasis via binding to cofilin.ONCOTARGET,5(11),3568-3578. |
| MLA | Huang, Xun,et al."JG6, a novel marine-derived oligosaccharide, suppresses breast cancer metastasis via binding to cofilin".ONCOTARGET 5.11(2014):3568-3578. |
入库方式： OAI收割
来源：上海药物研究所
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