Topsendines A-F, new 3-alkylpyridine alkaloids from a Hainan sponge Topsentia sp.
文献类型：期刊论文
| 作者 | Sun, Ji-Zheng2; Jiang, Cheng-Shi1; Chen, Xue-Qin1; Chen, Kao-Shan2; Zhen, Xue-Chu1; van Soest, Rob W. M.3; Guo, Yue-Wei1
|
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2014-05-13 |
| 卷号 | 70期号:19页码:3166-3171 |
| 关键词 | Sponge Topsentia sp. 3-Alkylpyridine alkaloid Topsendine Voltage-gated K+ channel |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2014.03.051 |
| 文献子类 | Article |
| 英文摘要 | Six new 3-alkylpyridine alkaloids, topsendines A-F (1-6), and one new naturally occurring product, 2-methyl-12-(pyridine-3-yl)dodecanal (7), were isolated from an undescribed species of Hainan sponge Topsentia. The structures of the new compounds were determined by extensive 2D NMR experiments, HR-EI/ESI-MS spectrometry measurements, and by comparison of their NMR data with those of structurally related compounds in the literature. In bioassay, compounds 1, 3, and 5 showed inhibitory actions on delayed rectifier K+ currents (I-K) in rat acutely dissociated hippocampal neurons at the concentration of 100 mu M, with the percentage of inhibition of 85.9 +/- 3.9%, 87.1 +/- 4.4%, and 76.2 +/- 12.2%, respectively. (c) 2014 Elsevier Ltd. All rights reserved. |
| WOS关键词 | SOUTH CHINA SEA ; ANTINEOPLASTIC PYRIDINE ALKALOIDS ; RECTIFIER K+ CHANNEL ; MARINE SPONGE ; AMPHIMEDON SP ; SIDE-CHAINS ; METABOLITES ; XESTOSPONGIA ; INHIBITION ; MECHANISM |
| 资助项目 | National Marine '863' Projects[2011AA09070102] ; National Marine '863' Projects[2013AA092902] ; National Natural Science Foundation of China[81273430] ; National Natural Science Foundation of China[21072204] ; National Natural Science Foundation of China[41306130] ; National Natural Science Foundation of China[81302692] ; SKLDR/SIMM Project[SIMM1203ZZ-03] ; China Postdoctoral Science Foundation Grant[2012M520956] ; EU 7th Framework Program-IRSES Project[246987] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000335274600009 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277078]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Guo, Yue-Wei |
| 作者单位 | 1.Chinese Acad Sci, Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Shandong Univ, Coll Life Sci, Jinan 250100, Peoples R China; 3.Univ Amsterdam, Zool Museum, NL-94766 Amsterdam, Netherlands |
| 推荐引用方式 GB/T 7714 | Sun, Ji-Zheng,Jiang, Cheng-Shi,Chen, Xue-Qin,et al. Topsendines A-F, new 3-alkylpyridine alkaloids from a Hainan sponge Topsentia sp.[J]. TETRAHEDRON,2014,70(19):3166-3171. |
| APA | Sun, Ji-Zheng.,Jiang, Cheng-Shi.,Chen, Xue-Qin.,Chen, Kao-Shan.,Zhen, Xue-Chu.,...&Guo, Yue-Wei.(2014).Topsendines A-F, new 3-alkylpyridine alkaloids from a Hainan sponge Topsentia sp..TETRAHEDRON,70(19),3166-3171. |
| MLA | Sun, Ji-Zheng,et al."Topsendines A-F, new 3-alkylpyridine alkaloids from a Hainan sponge Topsentia sp.".TETRAHEDRON 70.19(2014):3166-3171. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。