Regio- and Diastereoselective Construction of alpha-Hydroxy-delta-amino Ester Derivatives via 1,4-Conjugate Addition of beta,gamma-Unsaturated N-Sulfonylimines
文献类型：期刊论文
| 作者 | Qiu, Lin1; Gao, Lixin2; Tang, Jixing1; Wang, Dongwei1; Guo, Xin1; Liu, Shunying1; Yang, Liping1; Li, Jia1,2 ; Hu, Wenhao1
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
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| 出版日期 | 2014-05-02 |
| 卷号 | 79期号:9页码:4142-4147 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/jo500176g |
| 文献子类 | Article |
| 英文摘要 | A first example of 1,4-conjugate addition of beta,gamma-unsaturated N-sulfonylimines via the oxonium ylides trapping process was developed. This method afforded a novel and efficient access for the high regio- and diastereoselective construction of alpha-hydroxyl-delta-amino esters derivatives, which exhibit inhibitory activity on PTP1B and SIRT1 enzymes in vitro. The synthetic potentials and the biological activity of the resulting products were well demonstrated to be promising for drug discovery. |
| WOS关键词 | DIELS-ALDER REACTION ; ENANTIOSELECTIVE 3-COMPONENT REACTIONS ; CHIRAL BRONSTED ACID-RH-2(OAC)(4) ; ASYMMETRIC CONJUGATE ADDITION ; ALCOHOLIC OXONIUM YLIDE ; ALPHA,BETA-UNSATURATED IMINES ; MULTICOMPONENT REACTIONS ; 1,3-DICARBONYL COMPOUNDS ; COOPERATIVE CATALYSIS ; DIALKYLZINC REAGENTS |
| 资助项目 | Specialized Research Fund for the Doctoral Program of Higher Education[20100076110005] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000335490700045 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277083]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 |
| 通讯作者 | Liu, Shunying |
| 作者单位 | 1.E China Normal Univ, Dept Chem, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Shanghai 200062, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qiu, Lin,Gao, Lixin,Tang, Jixing,et al. Regio- and Diastereoselective Construction of alpha-Hydroxy-delta-amino Ester Derivatives via 1,4-Conjugate Addition of beta,gamma-Unsaturated N-Sulfonylimines[J]. JOURNAL OF ORGANIC CHEMISTRY,2014,79(9):4142-4147. |
| APA | Qiu, Lin.,Gao, Lixin.,Tang, Jixing.,Wang, Dongwei.,Guo, Xin.,...&Hu, Wenhao.(2014).Regio- and Diastereoselective Construction of alpha-Hydroxy-delta-amino Ester Derivatives via 1,4-Conjugate Addition of beta,gamma-Unsaturated N-Sulfonylimines.JOURNAL OF ORGANIC CHEMISTRY,79(9),4142-4147. |
| MLA | Qiu, Lin,et al."Regio- and Diastereoselective Construction of alpha-Hydroxy-delta-amino Ester Derivatives via 1,4-Conjugate Addition of beta,gamma-Unsaturated N-Sulfonylimines".JOURNAL OF ORGANIC CHEMISTRY 79.9(2014):4142-4147. |
入库方式： OAI收割
来源：上海药物研究所
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