中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Catalytic Asymmetric Alkylation of 3-Aryl- Substituted Oxindoles to give 3,3-Disubstituted Oxindoles under Phase- Transfer Conditions

文献类型:期刊论文

作者Deng, Fei1; Moteki, Shin A.2,3; Maruoka, Keiji2,3
刊名ASIAN JOURNAL OF ORGANIC CHEMISTRY
出版日期2014-04
卷号3期号:4页码:395-398
关键词alkylation asymmetric synthesis organocatalysis oxindoles phase-transfer reaction
ISSN号2193-5807
DOI10.1002/ajoc.201400011
文献子类Article
英文摘要An efficient enantioselective method for the construction of all-carbon quaternary stereocenters from 3-aryl-substituted oxindoles via asymmetric phase-transfer alkylation has been developed. The products are obtained in high yields and optical purity of up to 93% ee by using (S,S)-3,4,5-trifluorophenyl-NAS bromide as a chiral phase-transfer catalyst. The 3,3-disubstituted oxindole products are valuable intermediates for the synthesis of bioactive indole-containing natural products.
WOS关键词ORGANOCATALYTIC ALPHA-AMINATION ; BETA-KETO-ESTERS ; ENANTIOSELECTIVE SYNTHESIS ; INTRAMOLECULAR CYANOAMIDATION ; ALLYLIC ALKYLATION ; QUATERNARY STEREOCENTERS ; AMMONIUM-SALTS ; AMINO-ACIDS ; PALLADIUM ; DERIVATIVES
资助项目Shanghai Committee of Science and Technology, China[11ZR1444900] ; State Key Laboratory of Drug Research of China[SIMM1004KF-04]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000334789100008
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/277125]  
专题天然药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Deng, Fei
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Medica, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
2.Kyoto Univ, Grad Sch Sci, Dept Chem, Lab Synthet Organ Chem,Sakyo Ku, Kyoto 6068502, Japan;
3.Kyoto Univ, Grad Sch Sci, Dept Chem, Special Lab Organocatalyt Chem,Sakyo Ku, Kyoto 6068502, Japan
推荐引用方式
GB/T 7714
Deng, Fei,Moteki, Shin A.,Maruoka, Keiji. Catalytic Asymmetric Alkylation of 3-Aryl- Substituted Oxindoles to give 3,3-Disubstituted Oxindoles under Phase- Transfer Conditions[J]. ASIAN JOURNAL OF ORGANIC CHEMISTRY,2014,3(4):395-398.
APA Deng, Fei,Moteki, Shin A.,&Maruoka, Keiji.(2014).Catalytic Asymmetric Alkylation of 3-Aryl- Substituted Oxindoles to give 3,3-Disubstituted Oxindoles under Phase- Transfer Conditions.ASIAN JOURNAL OF ORGANIC CHEMISTRY,3(4),395-398.
MLA Deng, Fei,et al."Catalytic Asymmetric Alkylation of 3-Aryl- Substituted Oxindoles to give 3,3-Disubstituted Oxindoles under Phase- Transfer Conditions".ASIAN JOURNAL OF ORGANIC CHEMISTRY 3.4(2014):395-398.

入库方式: OAI收割

来源:上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。