Catalytic Asymmetric Alkylation of 3-Aryl- Substituted Oxindoles to give 3,3-Disubstituted Oxindoles under Phase- Transfer Conditions
文献类型：期刊论文
| 作者 | Deng, Fei1; Moteki, Shin A.2,3; Maruoka, Keiji2,3 |
| 刊名 | ASIAN JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2014-04 |
| 卷号 | 3期号:4页码:395-398 |
| 关键词 | alkylation asymmetric synthesis organocatalysis oxindoles phase-transfer reaction |
| ISSN号 | 2193-5807 |
| DOI | 10.1002/ajoc.201400011 |
| 文献子类 | Article |
| 英文摘要 | An efficient enantioselective method for the construction of all-carbon quaternary stereocenters from 3-aryl-substituted oxindoles via asymmetric phase-transfer alkylation has been developed. The products are obtained in high yields and optical purity of up to 93% ee by using (S,S)-3,4,5-trifluorophenyl-NAS bromide as a chiral phase-transfer catalyst. The 3,3-disubstituted oxindole products are valuable intermediates for the synthesis of bioactive indole-containing natural products. |
| WOS关键词 | ORGANOCATALYTIC ALPHA-AMINATION ; BETA-KETO-ESTERS ; ENANTIOSELECTIVE SYNTHESIS ; INTRAMOLECULAR CYANOAMIDATION ; ALLYLIC ALKYLATION ; QUATERNARY STEREOCENTERS ; AMMONIUM-SALTS ; AMINO-ACIDS ; PALLADIUM ; DERIVATIVES |
| 资助项目 | Shanghai Committee of Science and Technology, China[11ZR1444900] ; State Key Laboratory of Drug Research of China[SIMM1004KF-04] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000334789100008 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277125]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Deng, Fei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Medica, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Kyoto Univ, Grad Sch Sci, Dept Chem, Lab Synthet Organ Chem,Sakyo Ku, Kyoto 6068502, Japan; 3.Kyoto Univ, Grad Sch Sci, Dept Chem, Special Lab Organocatalyt Chem,Sakyo Ku, Kyoto 6068502, Japan |
| 推荐引用方式 GB/T 7714 | Deng, Fei,Moteki, Shin A.,Maruoka, Keiji. Catalytic Asymmetric Alkylation of 3-Aryl- Substituted Oxindoles to give 3,3-Disubstituted Oxindoles under Phase- Transfer Conditions[J]. ASIAN JOURNAL OF ORGANIC CHEMISTRY,2014,3(4):395-398. |
| APA | Deng, Fei,Moteki, Shin A.,&Maruoka, Keiji.(2014).Catalytic Asymmetric Alkylation of 3-Aryl- Substituted Oxindoles to give 3,3-Disubstituted Oxindoles under Phase- Transfer Conditions.ASIAN JOURNAL OF ORGANIC CHEMISTRY,3(4),395-398. |
| MLA | Deng, Fei,et al."Catalytic Asymmetric Alkylation of 3-Aryl- Substituted Oxindoles to give 3,3-Disubstituted Oxindoles under Phase- Transfer Conditions".ASIAN JOURNAL OF ORGANIC CHEMISTRY 3.4(2014):395-398. |
入库方式： OAI收割
来源：上海药物研究所
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