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BRCA1-Mediated Inflammation and Growth Activated & Inhibited Transition Mechanisms Between No-Tumor Hepatitis/Cirrhotic Tissues and HCC

文献类型：期刊论文

作者Diao, Haizhen1,2; Wang, Lin1,2; Huang, Juxiang1; Jiang, Minghu3; Zhou, Huilei1; Li, Xiaohe1; Chen, Qingchun1; Jiang, Zhenfu4; Feng, Haitao5
刊名JOURNAL OF CELLULAR BIOCHEMISTRY
出版日期2014-04
卷号115期号:4页码:641-650
关键词INFLAMMATION GROWTH BREAST CANCER 1 EARLY ONSET (BRCA1) HCC NO-TUMOR HEPATITIS CIRRHOTIC TISSUES (HBV OR HCV INFECTION)
ISSN号0730-2312
DOI10.1002/jcb.24699
文献子类Article
英文摘要To understand breast cancer 1 early onset (BRCA1)-mediated inflammation and growth activated and inhibited transition mechanisms between no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) and human hepatocellular carcinoma (HCC), BRCA1-activated different complete (all no positive correlation, Pearson correlation coefficient <0.25) and uncomplete (partly no positive correlation except BRCA1, Pearson <0.25) networks were identified in higher HCC compared with lower no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) from the corresponding BRCA1-stimulated (Pearson 0.25) or inhibited (Pearson -0.25) overlapping molecules of Pearson and GRNInfer, respectively. This result was verified by the corresponding scatter matrix. As visualized by GO, KEGG, GenMAPP, BioCarta, and disease database integration, we proposed mainly that BRCA1-stimulated different complete network was involved in BRCA1 activation with integral to membrane killer cell lectin-like receptor C to nucleus interferon regulatory factor 5-induced inflammation, whereas the corresponding inhibited network participated in BRCA1 repression with matrix roundabout axon guidance receptor homolog 1 to plasma membrane versican-induced growth in lower no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection). However, BRCA1-stimulated network contained BRCA1 activation with endothelium-specific to lysosomal transmembrane and carbamoyl synthetase to tastin, histone cluster and cyclin-induced growth, whereas the corresponding inhibited different complete network included BRCA1 repression with ovalbumin, thyroid stimulating hormone beta and Hu antigen C to cytochrome P450 to transducin-induced inflammation in higher HCC. Our BRCA1 different networks were verified by BRCA1-activated or -inhibited complete and uncomplete networks within and between no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) or (and) HCC. J. Cell. Biochem. 115: 641-650, 2014. (c) 2013 Wiley Periodicals, Inc.
WOS关键词SYSTEMS-THEORETICAL ANALYSIS ; CYCLE COMPUTATIONAL NETWORK ; HEPATOCELLULAR-CARCINOMA ; CLUSTER ; CANCER ; TRANSFORMATION ; CONSTRUCTION ; PROTEINS ; LAPTM4B ; SIGNAL
资助项目National Natural Science Foundation of China[61171114] ; State Key Laboratory of Drug Research[SIMM1302KF] ; Automatical Scientific Planning of Tsinghua University[20111081023] ; Automatical Scientific Planning of Tsinghua University[20111081010]
WOS研究方向Biochemistry & Molecular Biology ; Cell Biology
语种英语
WOS记录号WOS:000331088000005
出版者WILEY
源URL[http://119.78.100.183/handle/2S10ELR8/277147]  
专题新药研究国家重点实验室
中科院受体结构与功能重点实验室
通讯作者Wang, Lin
作者单位1.Beijing Univ Posts & Telecommun, Sch Elect Engn, Bioinformat Ctr, Beijing 100876, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
3.Tsinghua Univ, Sch Humanities & Social Sci, Lab Computat Linguist, Beijing 100084, Peoples R China;
4.China Univ Min & Technol, Sch Mech Elect & Informat Engn, Beijing 100083, Peoples R China;
5.Heilongjiang Univ Chinese Med, Harbin 150040, Peoples R China
推荐引用方式
GB/T 7714		 Diao, Haizhen,Wang, Lin,Huang, Juxiang,et al. BRCA1-Mediated Inflammation and Growth Activated & Inhibited Transition Mechanisms Between No-Tumor Hepatitis/Cirrhotic Tissues and HCC[J]. JOURNAL OF CELLULAR BIOCHEMISTRY,2014,115(4):641-650.
APA Diao, Haizhen.,Wang, Lin.,Huang, Juxiang.,Jiang, Minghu.,Zhou, Huilei.,...&Feng, Haitao.(2014).BRCA1-Mediated Inflammation and Growth Activated & Inhibited Transition Mechanisms Between No-Tumor Hepatitis/Cirrhotic Tissues and HCC.JOURNAL OF CELLULAR BIOCHEMISTRY,115(4),641-650.
MLA Diao, Haizhen,et al."BRCA1-Mediated Inflammation and Growth Activated & Inhibited Transition Mechanisms Between No-Tumor Hepatitis/Cirrhotic Tissues and HCC".JOURNAL OF CELLULAR BIOCHEMISTRY 115.4(2014):641-650.

入库方式： OAI收割

来源：上海药物研究所

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