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Synthesis of the cycloheptannelated indole fragment of dragmacidin E

文献类型：期刊论文

作者Wang, Bin1; Qin, Hua1; Zhang, Fengying1; Jia, Yanxing1,2
刊名TETRAHEDRON LETTERS
出版日期2014-02-26
卷号55期号:9页码:1561-1563
关键词Indole alkaloid Dragmacidin E Total synthesis Natural product
ISSN号0040-4039
DOI10.1016/j.tetlet.2014.01.063
文献子类Article
英文摘要Synthesis of the pivotal cycloheptannelated indole fragment of indole alkaloid dragmacidin E is achieved. The synthesis features a Pd-catalyzed indole synthesis reaction for the preparation of 3,7-disubstituted indole, a regioselective intramolecular Friedel Crafts reaction for the construction of the 3,4-bridged cycloheptannelated indole skeleton, and a coupling reaction of vinyl triflate with diorganocuprate. (C) 2014 Elsevier Ltd. All rights reserved.
WOS关键词WATER MARINE SPONGE ; EFFICIENT TOTAL-SYNTHESIS ; CROSS-COUPLING REACTIONS ; SUZUKI-MIYAURA REACTION ; 1ST TOTAL-SYNTHESIS ; ENANTIOSELECTIVE SYNTHESIS ; DIHYDROHAMACANTHIN-A ; BIOMIMETIC SYNTHESIS ; (+)-LYSERGIC ACID ; CLAVICIPITIC ACID
资助项目State Key Laboratory of Drug Research[00000000] ; National Natural Science Foundation of China[21290180] ; National Natural Science Foundation of China[20972007] ; National Basic Research Program of China (973 Program)[2010CB833200] ; Foundation of Ministry of Education of China[20120001110100]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000332434000012
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/277180]  
专题新药研究国家重点实验室
中科院受体结构与功能重点实验室
通讯作者Jia, Yanxing
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Media, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Bin,Qin, Hua,Zhang, Fengying,et al. Synthesis of the cycloheptannelated indole fragment of dragmacidin E[J]. TETRAHEDRON LETTERS,2014,55(9):1561-1563.
APA Wang, Bin,Qin, Hua,Zhang, Fengying,&Jia, Yanxing.(2014).Synthesis of the cycloheptannelated indole fragment of dragmacidin E.TETRAHEDRON LETTERS,55(9),1561-1563.
MLA Wang, Bin,et al."Synthesis of the cycloheptannelated indole fragment of dragmacidin E".TETRAHEDRON LETTERS 55.9(2014):1561-1563.

入库方式： OAI收割

来源：上海药物研究所

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