Structural Insights into Chitinolytic Enzymes and Inhibition Mechanisms of Selective Inhibitors
文献类型：期刊论文
| 作者 | Liu, Tian2; Chen, Lei2; Ma, Qiang1,2; Shen, Xu3 ; Yang, Qing2
|
| 刊名 | CURRENT PHARMACEUTICAL DESIGN
 |
| 出版日期 | 2014-02 |
| 卷号 | 20期号:5页码:754-770 |
| 关键词 | Chitin chitinase hexosaminidases crystal structure inhibitor |
| ISSN号 | 1381-6128 |
| DOI | 10.2174/138161282005140214164730 |
| 文献子类 | Article |
| 英文摘要 | Chitin biodegradation is linked to fungi cell differentiation, nematode egg hatching, arthropods morphogenesis and human defense against malaria and other pathogens infection as well. Two classes of enzymes for chitin degradation include glycosyl hydrolase (GH) family 18 chitinases and family 20 beta-N-acetyl-D-hexosaminidases. However, more and more research papers have revealed that either GH 18 family chitinases or GH 20 family beta-N-acetyl-D-hexosaminidases are a family composed of a number of isoforms, each of which plays an exclusive role in different life processes. The development of novel and specific inhibitors towards chitinolytic enzymes is of great importance in the investigation of or interference with chitin biodegradation. This review focuses on identified enzymes that are specifically involved in chitin degradation. And the latest progresses on crystal structures and specific inhibitors are summarized within the realm of this field. |
| WOS关键词 | BETA-N-ACETYLHEXOSAMINIDASE ; SUBSTRATE-ASSISTED CATALYSIS ; ACIDIC MAMMALIAN CHITINASE ; SCREENING-BASED DISCOVERY ; FAMILY 18 CHITINASES ; TAY-SACHS-DISEASE ; X-RAY-STRUCTURE ; CRYSTAL-STRUCTURE ; SERRATIA-MARCESCENS ; SANDHOFF-DISEASE |
| 资助项目 | National Key Project for Basic Research[2010CB126100] ; National Natural Science Foundation of China[31070715] ; National Natural Science Foundation of China[31101671] ; National High Technology Research and Development Program of China[2011AA10A204] ; National Key Technology RD Program[2011BAE06B05] ; Fundamental Research Funds for the Central Universities[DUT11RC(3)73] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000334306300007 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277195]  |
| 专题 | 药理学第三研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yang, Qing |
| 作者单位 | 1.Dalian Univ, Affiliated Zhongshan Hosp, Dalian 116001, Peoples R China; 2.Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian 116024, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Tian,Chen, Lei,Ma, Qiang,et al. Structural Insights into Chitinolytic Enzymes and Inhibition Mechanisms of Selective Inhibitors[J]. CURRENT PHARMACEUTICAL DESIGN,2014,20(5):754-770. |
| APA | Liu, Tian,Chen, Lei,Ma, Qiang,Shen, Xu,&Yang, Qing.(2014).Structural Insights into Chitinolytic Enzymes and Inhibition Mechanisms of Selective Inhibitors.CURRENT PHARMACEUTICAL DESIGN,20(5),754-770. |
| MLA | Liu, Tian,et al."Structural Insights into Chitinolytic Enzymes and Inhibition Mechanisms of Selective Inhibitors".CURRENT PHARMACEUTICAL DESIGN 20.5(2014):754-770. |
入库方式： OAI收割
来源：上海药物研究所
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