Monocarboxylate Transporter 4 Facilitates Cell Proliferation and Migration and Is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma Patients
文献类型：期刊论文
| 作者 | Zhu, Jiang1,2; Wu, Yu-Nong1; Zhang, Wei1; Zhang, Xiao-Min1; Ding, Xu1; Li, Huai-Qi1; Geng, Meiyu3 ; Xie, Zuo-Quan3; Wu, He-Ming1,2
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| 刊名 | PLOS ONE
 |
| 出版日期 | 2014-01-30 |
| 卷号 | 9期号:1 |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0087904 |
| 文献子类 | Article |
| 英文摘要 | Monocarboxylate transporter 4 (MCT4) is a cell membrane transporter of lactate. Recent studies have shown that MCT4 is over-expressed in various cancers; however, its role in cancer maintenance and aggressiveness has not been fully demonstrated. This study investigated the role of MCT4 in oral squamous cell carcinoma (OSCC), and found that it is highly expressed in OSCC patients by using immunohistochemistry. Moreover, this over-expression of MCT4 was closely associated with tumor size, TNM classification, lymphatic metastasis, distant metastasis and tumor recurrence, and also poor prognosis. To further study mechanisms of MCT4 in vitro, we used small-interfering RNA to silence its expression in OSCC cell lines. The results showed that knock-down of MCT4 decreased cell proliferation, migration, and invasion. The inhibition of proliferation was associated with down-regulation of p-AKT and p-ERK1/2, while decreased cell migration and invasion may be caused by down-regulation of integrin beta 4-SRC-FAK and MEK-ERK signaling. Together, these findings provide new insight into the critical role of MCT4 in cell proliferation and metastasis in OSCC. |
| WOS关键词 | FOCAL-ADHESION KINASE ; SIGNALING PATHWAYS ; CANCER CELLS ; E-CADHERIN ; TYROSINE PHOSPHORYLATION ; LACTATE ; HEAD ; SRC ; MCT4 ; FAK |
| 资助项目 | National Natural Science Foundation of China[81202549] ; National Science and Technology Major Project of the Ministry of Science and Technology of China[2012ZX09301001-007] ; Priority Academic Program Development of Jiangsu Higher Education Institutions[jx10531801/005] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000330617100120 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277218]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Xie, Zuo-Quan |
| 作者单位 | 1.Stomatol Hosp Jiangsu Prov, Dept Oral & Maxillofacial Surg, Nanjing, Jiangsu, Peoples R China; 2.Nanjing Med Univ, Inst Stomatol, Nanjing, Jiangsu, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Jiang,Wu, Yu-Nong,Zhang, Wei,et al. Monocarboxylate Transporter 4 Facilitates Cell Proliferation and Migration and Is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma Patients[J]. PLOS ONE,2014,9(1). |
| APA | Zhu, Jiang.,Wu, Yu-Nong.,Zhang, Wei.,Zhang, Xiao-Min.,Ding, Xu.,...&Wu, He-Ming.(2014).Monocarboxylate Transporter 4 Facilitates Cell Proliferation and Migration and Is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma Patients.PLOS ONE,9(1). |
| MLA | Zhu, Jiang,et al."Monocarboxylate Transporter 4 Facilitates Cell Proliferation and Migration and Is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma Patients".PLOS ONE 9.1(2014). |
入库方式： OAI收割
来源：上海药物研究所
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