Progress in Studies of Structure, Mechanism and Antagonists Interaction of GPCR Co-Receptors for HIV
文献类型：期刊论文
| 作者 | Zhong, Bing1; Zhen, Yunmei2; Qin, Guangrong1; Yang, Huaiyu1; Jiang, Hualiang1 ; Chen, Guanghui2; Yu, Kunqian1
|
| 刊名 | CURRENT PHARMACEUTICAL BIOTECHNOLOGY
 |
| 出版日期 | 2014 |
| 卷号 | 15期号:10页码:938-950 |
| 关键词 | CCR5 computational methods crystal structure CXCR4 HIV small molecular antagonists |
| ISSN号 | 1389-2010 |
| DOI | 10.2174/1389201015666141031120836 |
| 文献子类 | Article |
| 英文摘要 | Chemokine receptors are G protein-coupled receptors that contain seven trans-membrane domains. CXCR4 and CCR5 as major co-receptors for HIV-1 entry into host cells are implicated in cancer and inflammation. They have been attractive targets for the pharmaceutical industry basing on their roles in HIV disease. Homology modeling, molecular docking, molecular dynamics, Molecular Mechanics/Generalized Born Surface Area and many other computational methods are applied to illustrate the structure, function and binding site of GPCR. Moreover, the high resolution crystal structures of CXCR4 and CCR5 have provided extremely valuable structural information and receptor activation mechanisms, enable structure-based drug discovery for the treatment of HIV-1 infection. We also describe the recent progress about the small molecule antagonists of CXCR4 and CCR5 and the interaction between GPCR and their ligands predicted by molecular docking and molecular dynamics methods. Future research questions and further investigations are outlined to highlight some researches that may be relevant to the advancement of therapies targeting the important receptor related with HIV. |
| WOS关键词 | IMMUNODEFICIENCY-VIRUS TYPE-1 ; SMALL-MOLECULE CCR5 ; SELECTIVE ANTI-HIV-1 ACTIVITY ; PROTEIN-COUPLED RECEPTOR ; CXCR4 CHEMOKINE RECEPTOR ; 2ND EXTRACELLULAR LOOP ; ENTRY INHIBITORS ; BINDING-SITES ; POTENT INHIBITORS ; HIGHLY POTENT |
| 资助项目 | National High Technology Research and Development Program of China (863 Program)[2012AA020301] ; National High Technology Research and Development Program of China (863 Program)[2012AA01A305] ; Chinese Academy of Sciences Project[KSZD-EW-L09-4] ; National Natural Science Foundation of China[81230076] ; National Natural Science Foundation of China[21210003] ; National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program"[2013ZX09507001] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000345277000005 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277255]  |
| 专题 | 药物发现与设计中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yu, Kunqian |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Shantou Univ, Dept Biol, Shantou 515063, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhong, Bing,Zhen, Yunmei,Qin, Guangrong,et al. Progress in Studies of Structure, Mechanism and Antagonists Interaction of GPCR Co-Receptors for HIV[J]. CURRENT PHARMACEUTICAL BIOTECHNOLOGY,2014,15(10):938-950. |
| APA | Zhong, Bing.,Zhen, Yunmei.,Qin, Guangrong.,Yang, Huaiyu.,Jiang, Hualiang.,...&Yu, Kunqian.(2014).Progress in Studies of Structure, Mechanism and Antagonists Interaction of GPCR Co-Receptors for HIV.CURRENT PHARMACEUTICAL BIOTECHNOLOGY,15(10),938-950. |
| MLA | Zhong, Bing,et al."Progress in Studies of Structure, Mechanism and Antagonists Interaction of GPCR Co-Receptors for HIV".CURRENT PHARMACEUTICAL BIOTECHNOLOGY 15.10(2014):938-950. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。