Repair of methyl lesions in RNA by oxidative demethylation
文献类型：期刊论文
| 作者 | Ye, Fei2; Zhang, Liyi1; Jin, Lu1; Zheng, Mingyue1 ; Jiang, Hualiang1; Luo, Cheng1
|
| 刊名 | MEDCHEMCOMM
 |
| 出版日期 | 2014 |
| 卷号 | 5期号:12页码:1797-1803 |
| ISSN号 | 2040-2503 |
| DOI | 10.1039/c4md00256c |
| 文献子类 | Review |
| 英文摘要 | Nucleic acid methylation is one of the most important epigenetic modifications that have been studied intensively for the past several decades. Many diseases, such as cancer, neurological diseases and developmental defects, are closely associated with alkylation damage of nucleic acids. Although the majority of research on nucleic acid modification involves DNA methylation, RNA is also extensively modified. RNA methylation is a common and naturally occurring modification in both prokaryotic and eukaryotic organisms. The methylation of N6- methyladenine (m(6)A) is the most abundant modification in RNA and plays a fundamental regulatory role in gene expression. Alkylation damage in RNA can be repaired by RNA demethylases, including Escherichia coli AlkB and human AlkB homologues ALKBH1, ALKBH3, ALKBH5 and FTO. ALKBH5 and FTO are the only two m(6)A RNA demethylases identified so far. In this review, recent findings on RNA demethylases as well as biological functions and inhibitors will be discussed. |
| WOS关键词 | OBESITY-ASSOCIATED FTO ; MESSENGER-RNA ; MAMMALIAN RNA ; ALKYLATION DAMAGE ; CRYSTAL-STRUCTURE ; ESCHERICHIA-COLI ; OLD MODIFICATION ; DNA-DAMAGE ; FAT MASS ; GENE |
| 资助项目 | Hi-Tech Research and Development Program of China[2012AA020302] ; National Natural Science Foundation of China[81230076] ; National Natural Science Foundation of China[81402849] ; National Natural Science Foundation of China[21210003] ; National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program"[2013ZX09507-004] ; National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program"[2013ZX09507001] ; Zhejiang Province Natural Science Foundation[LQ14H300003] ; Zhejiang Provincial Top Key Discipline of Biology[00000000] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000345455600003 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277256]  |
| 专题 | 药物发现与设计中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Luo, Cheng |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China 2.Zhejiang Sci Tech Univ, Coll Life Sci, Hangzhou, Zhejiang, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Ye, Fei,Zhang, Liyi,Jin, Lu,et al. Repair of methyl lesions in RNA by oxidative demethylation[J]. MEDCHEMCOMM,2014,5(12):1797-1803. |
| APA | Ye, Fei,Zhang, Liyi,Jin, Lu,Zheng, Mingyue,Jiang, Hualiang,&Luo, Cheng.(2014).Repair of methyl lesions in RNA by oxidative demethylation.MEDCHEMCOMM,5(12),1797-1803. |
| MLA | Ye, Fei,et al."Repair of methyl lesions in RNA by oxidative demethylation".MEDCHEMCOMM 5.12(2014):1797-1803. |
入库方式： OAI收割
来源：上海药物研究所
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