Three pairs of variecolortide enantiomers from Eurotium sp with caspase-3 inhibitory activity
文献类型：期刊论文
| 作者 | Chen, Guo-Dong4,5; Bao, Yan-Ru4; Huang, Yuan-Fan4; Hu, Dan4; Li, Xiao-Xia4; Guo, Liang-Dong1; Li, Jia2,3 ; Yao, Xin-Sheng4; Gao, Hao4
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2014-01 |
| 卷号 | 92页码:252-259 |
| 关键词 | Eurotium sp. Variecolortides Caspase-3 inhibitor |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2013.11.012 |
| 文献子类 | Article |
| 英文摘要 | 7-O-methylvariecolortide A (1), variecolortide B (2), and variecolortide C (3), the rare variecolortides existing in racemic manner, were isolated from an endolichenic fungal strain Eurotium sp. (No. 17-11-8-1). With the chiral HPLC technology, (-)-(S)-7-O-methylvariecolortide A (1a), (+)-(R)-7-O-methylvariecolortide A (1b), (-)-(S)-variecolortide B (2a), (+)-(R)-variecolortide B (2b), (-)-(S)-variecolortide C (3a), and (+)-(R)-variecolortide C (3b) were successfully separated and obtained. Their absolute configurations were firstly assigned by ECD experiment and ECD calculation. According to the relation of isolated compounds, a plausible biosynthetic pathway for variecolortides was proposed. In caspase-3 enzymatic assay, compounds 1-3 showed inhibitory activity, with IC50 values of 1.7, 0.8 and 15.7 mu M, respectively. (C) 2013 Elsevier B.V. All rights reserved. |
| WOS关键词 | ENDOPHYTIC FUNGUS ; CHAETOMIUM-ELATUM ; ISOQUINOLINE-1,3,4-TRIONE ; ALKALOIDS ; RUBRUM ; STRAIN |
| 资助项目 | Ministry of Science and Technology of China[2012ZX09301002-003] ; Natural Science Foundation of China[81373306] ; Natural Science Foundation of China[81202441] ; Guangdong Natural Science Funds for Distinguished Young Scholar[S2013050014287] ; program for New Century Excellent Talents in University[NCET-10-0120] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000331420300032 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277310]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 |
| 通讯作者 | Yao, Xin-Sheng |
| 作者单位 | 1.Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100190, Peoples R China; 2.Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China; 3.Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 4.Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China; 5.South China Agr Univ, Dept Pharmaceut Engn, Guangzhou 510642, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Guo-Dong,Bao, Yan-Ru,Huang, Yuan-Fan,et al. Three pairs of variecolortide enantiomers from Eurotium sp with caspase-3 inhibitory activity[J]. FITOTERAPIA,2014,92:252-259. |
| APA | Chen, Guo-Dong.,Bao, Yan-Ru.,Huang, Yuan-Fan.,Hu, Dan.,Li, Xiao-Xia.,...&Gao, Hao.(2014).Three pairs of variecolortide enantiomers from Eurotium sp with caspase-3 inhibitory activity.FITOTERAPIA,92,252-259. |
| MLA | Chen, Guo-Dong,et al."Three pairs of variecolortide enantiomers from Eurotium sp with caspase-3 inhibitory activity".FITOTERAPIA 92(2014):252-259. |
入库方式： OAI收割
来源：上海药物研究所
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