Molecularly targeted cancer therapy: some lessons from the past decade
文献类型：期刊论文
| 作者 | Huang, Min ; Shen, Aijun; Ding, Jian; Geng, Meiyu
|
| 刊名 | TRENDS IN PHARMACOLOGICAL SCIENCES
 |
| 出版日期 | 2014-01 |
| 卷号 | 35期号:1页码:41-50 |
| 关键词 | tumor heterogeneity resistance personalized medicine biomarker co-clinical trial |
| ISSN号 | 0165-6147 |
| DOI | 10.1016/j.tips.2013.11.004 |
| 文献子类 | Review |
| 英文摘要 | The tremendous advances achieved in the understanding of cancer biology have delivered unprecedented progress in molecularly targeted cancer therapy in the past decade. The fast growing category of targeted anticancer agents available for clinical use is accompanied by a, conceptual revolution in anticancer drug development. Nevertheless, molecularly targeted cancer therapy remains challenged by a high failure rate and an extremely small proportion of patients that can benefit. It is pivotal to take lessons from the past and seek new solutions. This review discusses conceptual progress and remaining challenges in molecularly targeted cancer therapy, and proposes feasible alternatives to increase chances of clinical success in the future. |
| WOS关键词 | CELL LUNG-CANCER ; METASTATIC COLORECTAL-CANCER ; CHRONIC MYELOID-LEUKEMIA ; TYROSINE KINASE INHIBITOR ; FACTOR RECEPTOR MUTATIONS ; K-RAS MUTATIONS ; PERSONALIZED MEDICINE ; BREAST-CANCER ; EGFR MUTATION ; PREDICTIVE BIOMARKERS |
| 资助项目 | National Natural Science Foundation of China[81222049] ; Shanghai Metropolitan Government[12PJ1410400] ; National Science and Technology Major Project[2012ZX09301001-007] ; National Program on Key Basic Research Project of China of the Ministry of Science and Technology of China[2012CB910704] ; Natural Science Foundation of China for Innovation Research Group[81021062] ; Pujiang Scholar Program[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000330197300006 |
| 出版者 | ELSEVIER SCIENCE LONDON |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277322]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Ding, Jian |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Min,Shen, Aijun,Ding, Jian,et al. Molecularly targeted cancer therapy: some lessons from the past decade[J]. TRENDS IN PHARMACOLOGICAL SCIENCES,2014,35(1):41-50. |
| APA | Huang, Min,Shen, Aijun,Ding, Jian,&Geng, Meiyu.(2014).Molecularly targeted cancer therapy: some lessons from the past decade.TRENDS IN PHARMACOLOGICAL SCIENCES,35(1),41-50. |
| MLA | Huang, Min,et al."Molecularly targeted cancer therapy: some lessons from the past decade".TRENDS IN PHARMACOLOGICAL SCIENCES 35.1(2014):41-50. |
入库方式： OAI收割
来源：上海药物研究所
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