Scapiformolactones A-I: Germacrane sesquiterpenoids with an unusual Delta(3)-15,6-lactone moiety from Salvia scapiformis
文献类型：期刊论文
| 作者 | Lai, Yongji2; Xue, Yongbo2; Zhang, Mengke2; Zhang, Jinwen3; Tang, Wei4 ; Liu, Junjun2; Lei, Liang2; Yan, Juming1; Luo, Zengwei2; Zuo, Jianping4
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| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2013-12 |
| 卷号 | 96页码:378-388 |
| 关键词 | Salvia scapiformis Lamiaceae Germacrane sesquiterpene Conformation Chemical transformation Quantum mechanical calculation Cytotoxicity Immunomodulatory activity |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2013.10.003 |
| 文献子类 | Article |
| 英文摘要 | Nine germacrane sesquiterpenoids with an unusual Delta(3)-15,6-lactone moiety, scapiformolactones A-I (1-9), and one known seco-germacrane sesquiterpenoid, 3,7,11-trimethyldodeca-1,6,9-triene-3,11-diol (10), were isolated from whole plants of Salvia scapiformis Hance. Their structures were elucidated by spectroscopic methods including HR-ESIMS, IR, UV, NMR, and CD, as well as by quantum mechanical calculations and chemical transformations. Structures of compounds 1-3 were also confirmed by single-crystal X-ray diffraction analysis. Six germacrane 6,15-diol derivatives (11-16) were obtained by chemical transformation. Compounds 1-9 and 11-16 were evaluated for their in vitro immunomodulatory effects on T and B cells, as well as their in vitro cytotoxicity against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW480. (C) 2013 Elsevier Ltd. All rights reserved. |
| WOS关键词 | DIELS-F TOMENTOSA ; ROBOROWSKII ; ESTERS |
| 资助项目 | Hubei Key Laboratory Foundation of Natural Medicinal Chemistry and Resource Evaluation[00000000] ; Huazhong University of Science and Technology[2010-3] ; Fundamental Research Funds for the Central Universities[HUST: 2012QN003] ; Scientific Research Foundation for the Returned Oversea Chinese Scholars[00000000] ; State Education Ministry of China[2010-1561] ; State Education Ministry of China[40th] ; State Education Ministry of China[NCET-2008-0224] ; Program for New Century Excellent Talents in University[00000000] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000328869500040 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277349]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yao, Guangmin |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China; 3.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Lai, Yongji,Xue, Yongbo,Zhang, Mengke,et al. Scapiformolactones A-I: Germacrane sesquiterpenoids with an unusual Delta(3)-15,6-lactone moiety from Salvia scapiformis[J]. PHYTOCHEMISTRY,2013,96:378-388. |
| APA | Lai, Yongji.,Xue, Yongbo.,Zhang, Mengke.,Zhang, Jinwen.,Tang, Wei.,...&Zhang, Yonghui.(2013).Scapiformolactones A-I: Germacrane sesquiterpenoids with an unusual Delta(3)-15,6-lactone moiety from Salvia scapiformis.PHYTOCHEMISTRY,96,378-388. |
| MLA | Lai, Yongji,et al."Scapiformolactones A-I: Germacrane sesquiterpenoids with an unusual Delta(3)-15,6-lactone moiety from Salvia scapiformis".PHYTOCHEMISTRY 96(2013):378-388. |
入库方式： OAI收割
来源：上海药物研究所
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