Concealing cellular defects in pluripotent stem cells
文献类型：期刊论文
| 作者 | Zhang, Weiqi2; Qu, Jing2,6; Suzuki, Keiichiro3; Liu, Guang-Hui2,4,5; Izpisua Belmonte, Juan Carlos1,3 |
| 刊名 | TRENDS IN CELL BIOLOGY
 |
| 出版日期 | 2013-12 |
| 卷号 | 23期号:12页码:587-592 |
| 关键词 | pluripotent stem cell reprogramming disease modeling |
| ISSN号 | 0962-8924 |
| DOI | 10.1016/j.tcb.2013.07.001 |
| 文献子类 | Review |
| 英文摘要 | Inherent and acquired defects in gene expression, protein homeostasis, metabolic pathways, and organelle function are linked to aging and a wide range of human diseases. Although concealed or dormant in the embryonic stage, they often manifest later in life. We review and discuss recent observations on how somatic cells bearing specific phenotypic defects can be reprogrammed into a pluripotent state where most phenotypic abnormalities can be reset or tolerated. Gaining insights into the tolerance of cellular defects in pluripotent stem cells will facilitate our understanding of the properties of reprogrammed cells and may provide theoretical guidance for induced pluripotent stem cell based disease modeling and clinical therapies. |
| WOS关键词 | FRAGILE-X-SYNDROME ; GENE CORRECTION ; GENERATION ; IPSCS ; DERIVATION ; MUTATIONS ; GENOME ; STATE ; MICE |
| 资助项目 | Strategic Priority Research Program of the Chinese Academy of Sciences[XDA01020312] ; National Natural Science Foundation of China (NSFC)[81271266] ; National Natural Science Foundation of China (NSFC)[31222039] ; National Natural Science Foundation of China (NSFC)[31201111] ; Thousand Young Talents program of China[00000000] ; National Laboratory of Biomacromolecules[2013kf05] ; National Laboratory of Biomacromolecules[2013kf11] ; State Key Laboratory of Drug Research[SIMM1302KF-17] ; California Institute for Regenerative Medicine (CIRM) fellowship[00000000] ; TERCEL-ISCIII-MINECO[00000000] ; CIBER[00000000] ; Fundacion Cellex[00000000] ; G. Harold and Leila Y. Mathers Charitable Foundation[00000000] ; Sanofi[00000000] ; Leona M. and Harry B. Helmsley Charitable Trust[00000000] ; Ellison Medical Foundation[00000000] |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000328596700002 |
| 出版者 | ELSEVIER SCIENCE LONDON |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277351]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Liu, Guang-Hui |
| 作者单位 | 1.Ctr Regenerat Med Barcelona, Barcelona 08003, Spain; 2.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China; 3.Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 5.Beijing Inst Brain Disorders, Beijing, Peoples R China; 6.Chinese Acad Sci, Core Facil Prot Res, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Weiqi,Qu, Jing,Suzuki, Keiichiro,et al. Concealing cellular defects in pluripotent stem cells[J]. TRENDS IN CELL BIOLOGY,2013,23(12):587-592. |
| APA | Zhang, Weiqi,Qu, Jing,Suzuki, Keiichiro,Liu, Guang-Hui,&Izpisua Belmonte, Juan Carlos.(2013).Concealing cellular defects in pluripotent stem cells.TRENDS IN CELL BIOLOGY,23(12),587-592. |
| MLA | Zhang, Weiqi,et al."Concealing cellular defects in pluripotent stem cells".TRENDS IN CELL BIOLOGY 23.12(2013):587-592. |
入库方式： OAI收割
来源：上海药物研究所
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